116247-30-4

Upstream product

• 391-02-6 4-hydroxy-7-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester 
• 370-35-4 diethyl 2-({[3-(trifluoromethyl)phenyl]amino}methylidene)propanedioate 
• 98-16-8 3-trifluoromethylaniline 

Downstream Products

• 116270-43-0 N-[5-(4-Chloro-7-trifluoromethyl-quinolin-3-yl)-[1,3,4]oxadiazol-2-ylmethyl]-benzamide 
• 116247-33-7 N-({[5-(4-Chloro-7-trifluoromethyl-quinolin-3-yl)-[1,3,4]oxadiazol-2-ylmethyl]-carbamoyl}-methyl)-benzamide 
• 137556-19-5 4-Hydroxy-7-trifluoromethyl-quinoline-3-carboxylic acid [1-(2-chloro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 116247-31-5 N-{4-[5-(4-Chloro-7-trifluoromethyl-quinolin-3-yl)-[1,3,4]oxadiazol-2-yl]-phenyl}-benzamide 
• 116247-32-6 N-[1-[5-(4-Chloro-7-trifluoromethyl-quinolin-3-yl)-[1,3,4]oxadiazol-2-yl]-2-(1H-indol-3-yl)-ethyl]-benzamide 
• 137556-18-4 4-hydroxy-7-trifluoromethyl-quinoline-3-carboxylic acid (4-methoxy-benzylidene)hydrazide 
• 137556-22-0 4-Hydroxy-7-trifluoromethyl-quinoline-3-carboxylic acid [1-(2-fluoro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 137556-17-3 4-Hydroxy-7-trifluoromethyl-quinoline-3-carboxylic acid [1-(3-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide 
• 1471178-03-6 1-(2,4-dichlorobenzyl)-4-oxo-7-(trifluoromethyl)-1,4-dihydroquinoline-3-carbohydrazide 
• 1471178-09-2 1-(2,4-dichlorobenzyl)-4-oxo-8-(trifluoromethyl)-1,4-dihydroquinoline-3-carbohydrazide 
• 1471178-05-8 1-(4-cyanobenzyl)-4-oxo-7-(trifluoromethyl)-1,4-dihydroquinoline-3-carbohydrazide 
• 1471178-11-6 1-(4-cyanobenzyl)-4-oxo-8-(trifluoromethyl)-1,4-dihydroquinoline-3-carbohydrazide 
• 1374631-63-6 4-(4-methyl-piperazin-1-yl)-3-(5-phenyl-[1,3,4]oxadiazol-2-yl)-7-trifluoromethyl-quinoline 

Relevant academic research and scientific papers

Synthesis, characterization and antimicrobial studies of some new trifluoromethyl quinoline-3-carbohydrazide and 1,3,4-oxadiazoles

The present paper describes the synthesis of two new series of 7-(trifluoromethyl)-4-hydroxy substituted quinoline carbohydrazide derivatives (6a-e and 7a-g) and N-alkyl-3-(5-phenyl-1,3,4-oxadiazol-2-yl)-7- (trifluoromethyl) quinolin-4-amine derivatives (9a-f). Newly synthesized compounds were characterized by spectral studies. The structure of 9a was evidenced by X-ray crystallographic study. Synthesized compounds were screened for their antibacterial performance against Mycobacterium smegmatis and Pseudomonas aeruginosa. Antifungal activity was also carried out on the fungal stains Candida albicans and Penicillium chrysogenum. Compounds 7a and 9c showed significant antimicrobial activity against all the tested microorganisms. Among all the compounds, 6d and 6e showed the lowest MIC value of 6.25 μg mL -1 against Mycobacterium smegmatis indicating these compounds can be possible future antituberculosis agents. 2014 the Partner Organisations.

Design and regioselective synthesis of trifluoromethylquinolone derivatives as potent antimicrobial agents

Three series of new trifluoromethyl substituted quinolone derivatives were synthesized (4a-f, 6a-f and 8a-f) from corresponding substituted anilines by multi-step reactions. The regioselective alkylation with different alkyl halides were carried out by approaching two different routes to get the final products in good yield. Newly synthesized compounds were characterized by spectral study and also by C, H, N analyses. Three dimensional structure of 2b and 4b were also confirmed by single crystal X-ray studies. The final compounds (4a-f, 6a-f and 8a-f) were screened for their in-vitro antibacterial and antifungal activity by well plate method (zone of inhibition). The results revealed that, compounds 4a, 6b, 6c and 8e showed significant antibacterial activity as compared to the standard drug Ciprofloxacin. The compound 8a was found to be a potent antifungal agent.

5-Substituted 2--7-trifluoromethyl-quinolin-3-yl>-1,3,4-oxadiazoles as Hypotensive Agents

The title compounds (IVa-h) have been synthesized starting from ethyl 7-trifluoromethyl-4-hydroxyquinoline-3-carboxylate and evaluated for their hypotensive activity.