116248-42-1 Usage
Imidazole class
Belonging to a class of organic compounds that contain a five-membered ring with two nitrogen atoms and one sulfur atom.
Nitro group
A functional group consisting of an oxygen atom double-bonded to a nitrogen atom (-NO2), which may indicate potential antimicrobial properties.
Phenylsulfonyl group
A functional group composed of a sulfur atom double-bonded to a phenyl ring (C6H5-S-), suggesting possible sulfonamide-like properties.
Biological activity
Imidazoles are known for their ability to interact with biological systems, which may lead to potential applications in pharmaceuticals and medicine.
Pharmaceutical applications
Due to their biological activity, imidazole compounds like this one are commonly found in pharmaceuticals and may have potential in drug development.
Antimicrobial potential
The presence of a nitro group in the compound may indicate its potential as an antimicrobial agent, useful in treating infections.
Sulfonamide-like properties
The phenylsulfonyl group may provide the compound with properties similar to sulfonamide antibiotics, which are used in the treatment of various infections.
Further research
Additional studies on the biological and pharmacological properties of this compound could reveal its potential in drug development and medical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 116248-42-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,6,2,4 and 8 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 116248-42:
(8*1)+(7*1)+(6*6)+(5*2)+(4*4)+(3*8)+(2*4)+(1*2)=111
111 % 10 = 1
So 116248-42-1 is a valid CAS Registry Number.
116248-42-1Relevant articles and documents
Lowering of 5-nitroimidazole's mutagenicity: Towards optimal antiparasitic pharmacophore
Crozet, Maxime D.,Botta, Celine,Gasquet, Monique,Curti, Christophe,Remusat, Vincent,Hutter, Sebastien,Chapelle, Olivier,Azas, Nadine,De Meo, Michel,Vanelle, Patrice
scheme or table, p. 653 - 659 (2009/09/08)
To improve the antiparasitic pharmacophore, 20 5-nitroimidazoles bearing an arylsulfonylmethyl group were prepared from commercial imidazoles. The antiparasitic activity of these molecules was assessed against Trichomonas vaginalis, the in vitro cytotoxicity was evaluated on human monocytes and the mutagenicity was determined by the Salmonella mutagenicity assay. All IC50 on T. vaginalis were below the one of metronidazole. The determination of the specificity indexes (SIs), defined as the ratios of the cytotoxic activity and the antitrichomonas activity, indicated that 11 derivatives had a SI over the one of metronidazole. Molecules, bearing an additional methyl group on the 2-position, showed a lower mutagenicity than metronidazole. Moreover, three derivatives were characterized by a low mutagenicity and an efficient antitrichomonas activity.
Vicarious Nucleophilic Substitution of Hydrogen in Imidazole Derivatives
Makosza, Mieczyslaw,Kwast, Ewa
, p. 287 - 292 (2007/10/02)
Nitroderivatives of imidazole react with carbanions containing leaving groups at the carbanion center yielding products of vicarious nucleophilic substitution of hydrogen at positions activated by the nitro group.Some aspects of the orientation pattern ar
