7205-98-3

Basic information

• Product Name: CHLOROMETHYL PHENYL SULFONE
• Synonyms: PHENYL CHLOROMETHYL SULFONE;CHLOROMETHYL PHENYL SULFONE;[(CHLOROMETHYL)SULFONYL]BENZENE;[(chloromethyl)sulphonyl]benzene;chloromethyl phenyl sulphone;(Phenylsulfonyl)chloromethane;Phenylsulfonylmethyl chloride;Ai3-09778
• CAS NO: 7205-98-3
• Molecular Formula: C₇H₇ClO₂S
• Molecular Weight: 190.65
• EINECS: 230-581-8
• Product Categories: Organic Building Blocks;Sulfones;Sulfur Compounds
• Mol File: 7205-98-3.mol
• Article Data: 23

Chemical Properties

• Melting Point: 51-53 °C(lit.)
• Boiling Point: 130 °C / 1mmHg
• Flash Point: >230 °F
• Appearance: /
• Density: 1.336 g/cm³
• Vapor Pressure: 0.000197mmHg at 25°C
• Refractive Index: 1.544
• Storage Temp.: 2-8°C
• Solubility: soluble in Methanol
• BRN: 2046644
• CAS DataBase Reference: CHLOROMETHYL PHENYL SULFONE(CAS DataBase Reference)
• NIST Chemistry Reference: CHLOROMETHYL PHENYL SULFONE(7205-98-3)
• EPA Substance Registry System: CHLOROMETHYL PHENYL SULFONE(7205-98-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 21
• Hazardous Substances Data: 7205-98-3(Hazardous Substances Data)

Usage

Description

Chloromethyl Phenyl Sulfone, with the molecular formula C7H7ClO2S, is an organosulfur compound that belongs to a class of chemical compounds characterized by their sulfur-containing carbon-to-hydrogen bonds. CHLOROMETHYL PHENYL SULFONE is notable for its unique chemical reactivity, which is attributed to the diverse oxidation states of sulfur and its ability to form stable compounds with all elements except the noble gases. The presence of both chloromethyl and phenyl groups in its structure suggests that it may serve as a reactive intermediate or precursor molecule in various chemical synthesis processes. However, the potential human health impacts of this compound need to be assessed, and exposure should be managed, particularly in industrial applications. Further investigation is required to understand its physical and chemical properties, toxicity, regulatory requirements, and practical applications.

Uses

Used in Chemical Synthesis:
Chloromethyl Phenyl Sulfone is used as a reactive intermediate for various chemical synthesis processes. Its unique chemical reactivity, due to the presence of sulfur and the ability to form stable compounds, makes it a valuable component in the creation of new molecules and materials.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Chloromethyl Phenyl Sulfone is used as a precursor molecule for the development of new drugs. Its potential role in drug synthesis could lead to the discovery of novel therapeutic agents with improved efficacy and safety profiles.
Used in Material Science:
Chloromethyl Phenyl Sulfone is used as a building block in the development of advanced materials. Its chemical properties may contribute to the creation of materials with unique characteristics, such as enhanced stability, reactivity, or selectivity, which could be beneficial in various applications, including electronics, energy storage, and environmental protection.
Used in Industrial Applications:
In industrial settings, Chloromethyl Phenyl Sulfone may be employed in the production of specialty chemicals, agrochemicals, or other industrial products. Its versatility as a reactive intermediate allows for its use in a wide range of applications, provided that appropriate safety measures are taken to mitigate potential health risks associated with its use.

InChI:InChI=1/C7H7ClO2S/c8-6-11(9,10)7-4-2-1-3-5-7/h1-5H,6H2

Upstream product

• 7205-94-9 chloromethyl phenyl sulfoxide 
• 873-55-2 sodium benzenesulfonate 
• 38009-92-6 2-chloro-1-phenyl-2-(phenylsulfonyl)ethanone 
• 74-97-5 chlorobromomethane 
• 515-42-4 sodium phenylsulfonate 
• 3112-85-4 methylphenylsulfonate 
• 100-68-5 methyl-phenyl-thioether 
• 108-98-5 thiophenol 
• 3406-03-9 2-(phenylsulfonyl)acetophenone 
• 565446-69-7 N-[3-(4-benzenesulfonyl-5-oxy-furazan-3-yloxy)-propyl]-N'-benzoyl-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine 
• 7647-01-0 hydrogenchloride 
• 67-56-1 methanol 
• 195371-23-4 p-Tolyl-chlorbrommethyl-sulfon 
• 7205-91-6 phenylthiomethyl chloride 

Downstream Products

• 70150-86-6 1-(chloro(phenylsulfonyl)methyl)cyclohexan-1-ol 
• 87505-13-3 1a,1b,2,7b-tetrahydro-1,2-bis(phenylsulfonyl)-1H-azirino<1.2-a>cyclopropa<1.8>naphthyridine 
• 87505-10-0 1a,1b,2,7b-tetrahydro-1,2-bis(phenylsulfonyl)-1H-azirino<1.2-a>cyclopropa<1.5>naphthyridine 
• 119872-45-6 7-Benzenesulfonylmethyl-3-chloro-6-nitro-1H-indazole 
• 109384-29-4 (1-Chloro-nonane-1-sulfonyl)-benzene 
• 92241-28-6 1-Benzenesulfonylmethyl-5-methoxy-2,4-dinitro-benzene 
• 92241-30-0 2-Benzenesulfonylmethyl-3-methoxy-1,4-dinitro-benzene 
• 127237-48-3 (Chloro-cyclohexylidene-methanesulfonyl)-benzene 
• 28937-60-2 2-phenylsulphonyl-1-oxaspiro<2.5>octane 
• 95339-49-4 methyl 2-cyano-3-phenyl-4-phenylsulphonyl-2-butenoate 
• 136289-44-6 <2-chloro-1-phenyl-2-(phenylsulphonyl)ethyl>propanedinitrile 
• 136289-43-5 1,1-Dicyano-2-phenyl-3-(phenylsulfonyl)propene 
• 86434-26-6 1-Benzenesulfonylmethyl-2-methyl-4-nitro-benzene 
• 86434-30-2 1-Benzenesulfonylmethyl-4-methyl-2-nitro-benzene 

Relevant articles and documents

Synthetic Studies on the Preparation of Alanyl Epoxysulfones as Cathepsin Cysteine Protease Electrophilic Traps

A Darzens reaction between tert-butoxycarbonyl alaninal and chloromethyl phenyl sulfone afforded chlorohydrins, which were converted into epoxysulfones by reaction with sodium tert-butoxide. Epoxysulfone 10 and chloroketone 14 derived from chlorohydrins by oxidation proved to be inhibitors of cathepsins H, S, and C as determined by competitive activity-based protein profiling.

Selectivity switch in the aerobic oxygenation of sulfides photocatalysed by visible-light-responsive decavanadate

Nanometre-sized metal oxides are promising species for the development of visible-light-responsive photocatalysts for the selective transformation of organic functional groups. In this article, we report that decavanadate ([V10O28]6-, V10) behaved as an efficient visible-light-responsive photocatalyst in the product-selective oxygenation of sulfides achieved using O2 (1 atm) as the green oxidant. In particular, we revealed that visible-light-responsive photocatalysis of V10 showed remarkable activity for the oxygenation of structurally diverse sulfides to form the corresponding sulfones using O2 in methyl ethyl ketone (MEK). Furthermore, by simply adding water to the reaction mixture, the product selectivity of sulfide oxygenation can be significantly switched toward the production of sulfoxides, without concomitant loss of photocatalytic activity. Based on experimental evidence, we inferred the following mechanistic steps for this photocatalytic system: the aerobic oxygenation of sulfides to form the corresponding sulfoxides initiated by a visible-light-induced photoredox reaction of V10. As for the formation of sulfones, MEK-derived peroxide species as the co-catalysts are probably involved in the oxygenation of sulfoxides to sulfones. The selectivity switch of the V10-photocatalysed reaction brought about by water addition is most likely achieved by suppressing the formation of MEK-derived peroxide species. This journal is

Controlled α-mono- and α,α-di-halogenation of alkyl sulfones using reagent-solvent halogen bonding

The direct and selective α-mono-bromination of alkyl sulfones was achieved through base-mediated electrophilic halogenation. The appropriate combination of solvent and electrophilic bromine source was found to be critical to control the nature of the products formed, where reagent-solvent halogen bonding is proposed to control the selectivity via alteration of the effective size of the electrophilic bromine source. Conversely, the α,α-di-brominated sulfones were selectively obtained in good yields following polyhalogenation followed by selective de-halogenation during workup. Both procedures can be applied on gram scale, and the mono-halogenation was successfully extended to the fully selective α-chlorination, α-iodination and α-fluorination of alkyl sulfones.