116249-71-9

Upstream product

• 26480-90-0 ethyl 2-(triphenyl-λ⁵-phosphanylidene)pent-4-enoate 
• 123-11-5 4-methoxy-benzaldehyde 
• 116145-51-8 2-(Bis-methylsulfanyl-methylene)-1-(4-methoxy-phenyl)-pent-4-en-1-ol 
• 97510-28-6 2-allyl-3,3-bis(methylthio)-1-(p-methoxyphenyl)prop-2-en-1-one 
• 172656-37-0 2-[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-pent-4-enoic acid ethyl ester 
• 116145-60-9 methyl (E)-2-(4-methoxybenzylidene)pent-4-enoate 
• 502180-40-7 2-[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-pent-4-enoic acid 

Relevant academic research and scientific papers

Efficient synthesis of α-benzylidene-γ-methyl-γ-butyrolactones

A concise synthesis of α-benzylidene-γ-methyl-γ-butyrolactones 5a - g from substituted benzaldehydes is described. Compounds 1a - g on reaction with phosphorane 2, provide the pentenoates 3a - g, which can be hydrolyzed to the acids 4a - g. The latter are cyclized to the corresponding butyrolactones 5a - g in excellent yields. The pentenoates 3a - g, on acid catalyzed cyclization, also provide 5a - g in very high yields.

POLARIZED KETENE DITHIOACETALS 63. STEREOSELECTIVE SYNTHESIS OF Α-YLIDENE-Γ-BUTYROLACTONES

A facile method for highly stereoselective synthesis of α-arylidene (4a-d, 4f-h and 4j) and α-ethylidene (4e,4i)-γ-butyrolactones has been developed by acid catalyzed lactonization of the corresponding α-ylidene-γ,δ-unsaturated esters 3a-j.The required es