116267-86-8

Upstream product

• 71333-60-3 (E)-1-Isocyano-2-phenyl-1-tosylethene 
• 93-55-0 1-phenyl-propan-1-one 
• 40167-34-8 methyl 4-phenyl-1H-pyrrole-3-carboxylate 

Relevant academic research and scientific papers

Targeted Synthesis of Regioisomerically Pure Dodecasubstituted Type i Porphyrins through the Exploitation of Peri-interactions

A targeted synthesis of dodecasubstituted type I porphyrins that utilizes the reaction of unsymmetrical 3,4-difunctionalized pyrroles and sterically demanding aldehydes was developed. This way, type I porphyrins could be obtained as the only type isomers, likely due to a minimization of the steric strain arising from peri-interactions. Uniquely, this method does not depend on lengthy precursor syntheses, the separation of isomers, or impractical limitations of the scale. In addition, single-crystal X-ray analysis was used to elucidate the structural features of the macrocycles.

3-Methyl-4-phenylpyrrole from the ants Anochetus kempfi and Anochetus mayri

The cephalic extracts of the ant Anochetus kempfi were found to contain 2,5-dimethyl-3-isoamylpyrazine (1) and 3-methyl-4-phenylpyrrole (2). The structures of these compounds were established from their spectral data and by comparison with synthetic samples. This is the first report of a phenylpyrrole found in an insect and only the third report of a pyrrole from ants.

Synthesis of 3,4-Disubstituted Pyrroles Bearing Substituents of Electron-Withdrawing and/or Electron-Donating Nature

The synthesis is described of a series of 3,4-disubstituted pyrroles 8 from 1-isocyano-1-tosyl-1-alkenes and a variety of Michael donors.It is possible to use this method for the synthesis of pyrroles that bear no electron-withdrawing substituents.