116270-54-3

Upstream product

• 94-09-7 p-aminoethylbenzoate 
• 3166-54-9 2-(chloromethyl)-3-(2-methylphenyl)-3H-quinazoline-4-one 

Downstream Products

• 116285-51-9 C₃₁H₂₈N₆O₂S 
• 116270-67-8 C₃₀H₂₅BrN₆O₂S 
• 116270-75-8 2-({4-[5-(4-Methoxy-phenylamino)-[1,3,4]thiadiazol-2-yl]-phenylamino}-methyl)-3-o-tolyl-3H-quinazolin-4-one 
• 116270-89-4 2-({4-[5-(4-Methoxy-phenylamino)-[1,3,4]oxadiazol-2-yl]-phenylamino}-methyl)-3-o-tolyl-3H-quinazolin-4-one 
• 116270-81-6 2-({4-[5-(4-Bromo-phenylamino)-[1,3,4]thiadiazol-2-yl]-phenylamino}-methyl)-3-o-tolyl-3H-quinazolin-4-one 
• 116270-94-1 2-({4-[5-(4-Bromo-phenylamino)-[1,3,4]oxadiazol-2-yl]-phenylamino}-methyl)-3-o-tolyl-3H-quinazolin-4-one 
• 116270-78-1 2-({4-[5-(4-Chloro-phenylamino)-[1,3,4]thiadiazol-2-yl]-phenylamino}-methyl)-3-o-tolyl-3H-quinazolin-4-one 
• 116270-91-8 2-({4-[5-(4-Chloro-phenylamino)-[1,3,4]oxadiazol-2-yl]-phenylamino}-methyl)-3-o-tolyl-3H-quinazolin-4-one 
• 116270-72-5 3-o-Tolyl-2-{[4-(5-p-tolylamino-[1,3,4]thiadiazol-2-yl)-phenylamino]-methyl}-3H-quinazolin-4-one 
• 116270-86-1 3-o-Tolyl-2-{[4-(5-p-tolylamino-[1,3,4]oxadiazol-2-yl)-phenylamino]-methyl}-3H-quinazolin-4-one 
• 116270-69-0 2-Phenylamino-5--1,3,4-thiadiazole 
• 116270-83-8 2-Phenylamino-5--1,3,4-oxadiazole 
• 116270-61-2 C₃₁H₂₈N₆O₃S 
• 116270-64-5 C₃₀H₂₅ClN₆O₂S 

Relevant academic research and scientific papers

Synthesis and Pharmacological Evaluation of N1--N4-arylthiosemicarbazides and 2-Arylamino-5--1,3,4-thiadiazoles/oxadiazoles as Oral Hypoglycemic Agents

A series of 2-arylamino-5--1,3,4-thiadiazoles/oxadiazoles (III/IV) have been synthesised from N1--N4-arylthiosemicarbazides (II) by treatment with conc. sulphuric acid or mercuric oxide.The thiosemicarbazides (II), in turn, have been prepared by refluxing 2--3-arylquinazolin-4(3H)-one (I) with various aryl isothiocyanates in abs. ethanol.A few of these compounds when tested on rats at an oral dose of 250 mg/kg, reduced the blood sugar to about 25 percent.