116270-87-2

Upstream product

• 116270-59-8 C₃₁H₂₈N₆O₃S 
• 22312-82-9 2-(chloromethyl)-3-(4-methoxyphenyl)quinazolin-4(3H)-one 
• 622-59-3 1-isothiocyanato-4-methylbenzene 
• 94-09-7 p-aminoethylbenzoate 
• 116270-55-4 2-<(p-Hydrazinocarbonyl)phenylaminomethyl>-3-(p-methoxyphenyl)quinazolin-4(3H)-one 
• 156672-71-8 4-{[3-(4-Methoxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-amino}-benzoic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis and Pharmacological Evaluation of N1--N4-arylthiosemicarbazides and 2-Arylamino-5--1,3,4-thiadiazoles/oxadiazoles as Oral Hypoglycemic Agents

A series of 2-arylamino-5--1,3,4-thiadiazoles/oxadiazoles (III/IV) have been synthesised from N1--N4-arylthiosemicarbazides (II) by treatment with conc. sulphuric acid or mercuric oxide.The thiosemicarbazides (II), in turn, have been prepared by refluxing 2--3-arylquinazolin-4(3H)-one (I) with various aryl isothiocyanates in abs. ethanol.A few of these compounds when tested on rats at an oral dose of 250 mg/kg, reduced the blood sugar to about 25 percent.