116312-69-7

Basic information

• Product Name: 1-(TETRAHYDRO-2H-PYRAN-4-YL)HYDRAZINE HYDROCHLORIDE
• Synonyms: (tetrahydro-2H-pyran-4-yl)hydrazine;Oxan-4-ylhydrazine dihydrochloride;Oxan-4-ylhydrazine;(Tetrahydro-2H-pyran-4-yl);EOS-62431
• CAS NO: 116312-69-7
• Molecular Formula: C₅H₁₂N₂O
• Molecular Weight: 152.62252
• Mol File: 116312-69-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 234.494°C at 760 mmHg
• Flash Point: 95.619°C
• Appearance: /
• Density: 1.045g/cm³
• Vapor Pressure: 0.053mmHg at 25°C
• Refractive Index: 1.49
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 7.28±0.20(Predicted)
• CAS DataBase Reference: 1-(TETRAHYDRO-2H-PYRAN-4-YL)HYDRAZINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(TETRAHYDRO-2H-PYRAN-4-YL)HYDRAZINE HYDROCHLORIDE(116312-69-7)
• EPA Substance Registry System: 1-(TETRAHYDRO-2H-PYRAN-4-YL)HYDRAZINE HYDROCHLORIDE(116312-69-7)

Safety Data

• Hazardous Substances Data: 116312-69-7(Hazardous Substances Data)

Usage

General Description

1-(Tetrahydro-2H-pyran-4-yl)hydrazine hydrochloride is a chemical compound that is commonly used in organic synthesis and pharmaceutical research. It is a hydrazine derivative with a tetrahydro-2H-pyran-4-yl group. The compound is typically used as a reagent in the preparation of various organic compounds, including pharmaceutical agents and agrochemicals. Its hydrochloride salt form enhances its solubility and stability, making it easier to handle and store. 1-(TETRAHYDRO-2H-PYRAN-4-YL)HYDRAZINE HYDROCHLORIDE has potential applications in the development of new drugs and agrochemicals due to its unique chemical structure and properties.

InChI:InChI=1/C5H12N2O/c6-7-5-1-3-8-4-2-5/h5,7H,1-4,6H2

Upstream product

• 97986-34-0 toluene-4-sulfonic acid tetrahydropyran-4-yl ester 
• 134419-59-3 4-oxanyl methanesulfonate 
• 693287-78-4 N’-(tetrahydropyran-4-ylidene)hydrazinecarboxylic acid tert-butyl ester 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 693287-79-5 N’-(tetrahydropyran-4-yl)hydrazinecarboxylic acid tert-butyl ester 

Downstream Products

• 950859-30-0 ethyl 5-amino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxylate 
• 1247075-24-6 3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-amine 

Relevant articles and documents

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

The present study describes the discovery and characterization of a series of 5-aryl-2H-tetrazol-3-ylacetamides as G protein-gated inwardly-rectifying potassium (GIRK) channels activators. Working from an initial hit discovered during a high-throughput screening campaign, we identified a tetrazole scaffold that shifts away from the previously reported urea-based scaffolds while remaining effective GIRK1/2 channel activators. In addition, we evaluated the compounds in Tier 1 DMPK assays and have identified a (3-methyl-1H-pyrazol-1-yl)tetrahydrothiophene-1,1-dioxide head group that imparts interesting and unexpected microsomal stability compared to previously-reported pyrazole head groups.

AZAINDAZOLES

Herein are disclosed azaindazoles of formula (I), (I), where the various groups are defined herein, and which are useful for treating cancer.

PI3K/MTOR KINASE INHIBITORS

6-morpholin-4-yl-pyrazolo[3,4-d]pyrimidine and 2-morpholin-4-yl-7H- pyrrolo[2,3-d]pyrimidine derivatives have unexpected drug properties as inhibitors of PI3 and/or mTOR kinases and are useful in treating disorders related to abnormal PI3K/mT0R activities such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders.