(Tetrahydro-2H-pyran-4-yl)hydrazine

Base Information

• Chemical Name: (Tetrahydro-2H-pyran-4-yl)hydrazine
• CAS No.: 116312-69-7
• Molecular Formula: C5H12N2O
• Molecular Weight: 116.163
• European Community (EC) Number: 800-259-7
• DSSTox Substance ID: DTXSID00434785
• Mol file: 116312-69-7.mol

Synonyms:(Tetrahydro-2H-pyran-4-yl)hydrazine;116312-69-7;Oxan-4-ylhydrazine;1-(tetrahydro-2H-pyran-4-yl)hydrazine;(TETRAHYDRO-PYRAN-4-YL)-HYDRAZINE;Hydrazine, (tetrahydro-2H-pyran-4-yl)-;(oxan-4-yl)hydrazine;4-hydrazinotetrahydropyran;SCHEMBL7890;DTXSID00434785;CMXVPHSHKFQSHM-UHFFFAOYSA-N;tetrahydro-2H-pyran-4-ylhydrazine;CS-B0289;Tetrahydro-2H-pyran-4-yl-hydrazine;MFCD09745200;tetrahydro-2H-pyran-4-ylamino amine;AKOS009623125;SB21655;CS-13414;FT-0696934;F51905;A893587

Chemical Property of (Tetrahydro-2H-pyran-4-yl)hydrazine

Chemical Property:

• Vapor Pressure: 0.053mmHg at 25°C
• Boiling Point: 234.494oC at 760 mmHg
• PKA: 7.28±0.20(Predicted)
• Flash Point: 95.619oC
• PSA: 47.28000
• Density: 1.045g/cm3
• LogP: 2.32390
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 116.094963011
• Heavy Atom Count: 8
• Complexity: 61.4

Purity/Quality:

97% ^*data from raw suppliers

(Tetrahydro-2H-pyran-4-yl)hydrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCC1NN

Technology Process of (Tetrahydro-2H-pyran-4-yl)hydrazine

There total 6 articles about (Tetrahydro-2H-pyran-4-yl)hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N’-(tetrahydropyran-4-yl)hydrazinecarboxylic acid tert-butyl ester (693287-79-5) → tetrahydro-2H-pyran-4-yl-hydrazine (116312-69-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

DOI:10.1021/jm030276s

Reference yield: 51.0%

4-oxanyl methanesulfonate (134419-59-3) → tetrahydro-2H-pyran-4-yl-hydrazine (116312-69-7)

Guidance literature:

With hydrazine; In ethanol; at 70 - 80 ℃; for 3 - 8h; Product distribution / selectivity;

Reference yield:

Tetrahydro-4H-pyran-4-one (29943-42-8,143562-54-3) → tetrahydro-2H-pyran-4-yl-hydrazine (116312-69-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / methanol / 20 °C

2: 100 percent / sodium cyanoborohydride; aq. acetic acid / 20 °C

3: 100 percent / CF₃CO₂H / CH₂Cl₂ / 20 °C

With sodium cyanoborohydride; acetic acid; trifluoroacetic acid; In methanol; dichloromethane;

DOI:10.1021/jm030276s

upstream raw materials:

N’-(tetrahydropyran-4-yl)hydrazinecarboxylic acid tert-butyl ester

Tetrahydro-4H-pyran-4-one

N’-(tetrahydropyran-4-ylidene)hydrazinecarboxylic acid tert-butyl ester

toluene-4-sulfonic acid tetrahydropyran-4-yl ester

Downstream raw materials:

4-aminotetrahydropyran

5-amino-1-(tetrahydropyran-4-yl)-1H-pyrazole-4-carboxylic acid amide

ethyl 5-amino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxylate

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