1163304-33-3Relevant academic research and scientific papers
Synthesis and analgesic evaluation of a series of proline-typed spiro cyclic quaternary ammoniums
Lin, Songwen,Wang, Na,Zhao, Shuo,Sun, Qi,Zhang, Weiwei,Ye, Jia,Cheng, Tieming,Li, Runtao
, p. 862 - 869 (2014)
A series of proline derivated spirocyclic quaternary ammoniums were synthesized and evaluated via in vivo analgesic activities. Compounds 9a showed the best analgesic effect with 84 % inhibition in mice. These compounds showed only micromolar Ki value by in vitro α7 nAChR binding test, which may indicate the form of active metabolite play a role in their in vitro analgesic activities.
