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N,O-Dimethylhydroxylamine hydrochloride Manufacturer/High quality/Best price/In stock
Cas No: 6638-79-5
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High quality N,O-Dimethylhydroxylamine Hydrochloride supplier in China
Cas No: 6638-79-5
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High purity Various Specifications N,O-Dimethylhydroxylamine hydrochloride CAS:6638-79-5
Cas No: 6638-79-5
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N,O-Dimethylhydroxylamine hydrochloride CAS NO.6638-79-5
Cas No: 6638-79-5
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Manufacturer high quality N,O-Dimethylhydroxylamine hydrochloride Cas 6638-79-5 with good price
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N,O-Dimethylhydroxylamine hydrochloride
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Factory Supply N,O-Dimethylhydroxylamine Hydrochloride
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N,O-Dimethylhydroxylamine hydrochloride
Cas No: 6638-79-5
USD $ 65.0-100.0 / Kilogram 1 Kilogram 100 Metric Ton/Year Sinoway Industrial Co., Ltd. Contact Supplier
N,O-Dimethylhydroxylamine hydrochloride
Cas No: 6638-79-5
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6638-79-5 Usage

Chemical Properties

N,O-Dimethylhydroxylamine hydrochloride is white to off-white crystals or crystalline powder

Uses

Different sources of media describe the Uses of 6638-79-5 differently. You can refer to the following data:
1. N,O-Dimethylhydroxylamine hydrochloride is used for preparation of an inhibitor of the NLS-derived BC peptides.
2. N,O-Dimethylhydroxylamine hydrochloride is used as a reagent in the preparation of 2-acyloxazoles from 2-oxazolemagnesium chloride and N-methoxy-N-methyl-3-oxo-butyramide from diketene. It is also used in amide coupling reactions to form Weinreb amides, which are useful in the Weinreb ketone synthesis. In addition, it is used in the preparation of an inhibitor of the NLS-derived BC peptides.
3. Reagent for the preparation of Weinreb amides recently used in the synthesis of 2-acyloxazoles from 2-oxazolemagnesium chloride.

Check Digit Verification of cas no

The CAS Registry Mumber 6638-79-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,6,3 and 8 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 6638-79:
(6*6)+(5*6)+(4*3)+(3*8)+(2*7)+(1*9)=125
125 % 10 = 5
So 6638-79-5 is a valid CAS Registry Number.
InChI:InChI=1/C2H7NO.ClH/c1-3-4-2;/h3H,1-2H3;1H

6638-79-5 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (D1899)  N,O-Dimethylhydroxylamine Hydrochloride  >98.0%(T) 6638-79-5 25g 180.00CNY Detail
TCI America (D1899)  N,O-Dimethylhydroxylamine Hydrochloride  >98.0%(T) 6638-79-5 100g 520.00CNY Detail
TCI America (D1899)  N,O-Dimethylhydroxylamine Hydrochloride  >98.0%(T) 6638-79-5 500g 1,790.00CNY Detail
Alfa Aesar (A17469)  N,O-Dimethylhydroxylamine hydrochloride, 98%    6638-79-5 5g 311.0CNY Detail
Alfa Aesar (A17469)  N,O-Dimethylhydroxylamine hydrochloride, 98%    6638-79-5 25g 818.0CNY Detail
Alfa Aesar (A17469)  N,O-Dimethylhydroxylamine hydrochloride, 98%    6638-79-5 100g 2305.0CNY Detail
Aldrich (D163708)  N,O-Dimethylhydroxylaminehydrochloride  98% 6638-79-5 D163708-5G 325.38CNY Detail
Aldrich (D163708)  N,O-Dimethylhydroxylaminehydrochloride  98% 6638-79-5 D163708-25G 1,248.39CNY Detail
Aldrich (D163708)  N,O-Dimethylhydroxylaminehydrochloride  98% 6638-79-5 D163708-100G 2,543.58CNY Detail

6638-79-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name N,O-Dimethylhydroxylamine hydrochloride

1.2 Other means of identification

Product number -
Other names DMH HYDROCHLORIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6638-79-5 SDS

6638-79-5Synthetic route

N,0-dimethylhydroxylamine
1117-97-1

N,0-dimethylhydroxylamine

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

Conditions
ConditionsYield
With hydrogenchloride37.1 g
4-amino-2-ethylsulfanylpyrimidine-5-carboxylic acid metoxymethylamide
741712-36-7

4-amino-2-ethylsulfanylpyrimidine-5-carboxylic acid metoxymethylamide

1-bromo-4,5-difluoro-2-methoxybenzene
202865-58-5

1-bromo-4,5-difluoro-2-methoxybenzene

A

(4-amino-2-ethylsulfanylpyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone
741713-37-1

(4-amino-2-ethylsulfanylpyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone

B

(4-amino-2-ethylsulfanylpyrimidin-5-yl)(4,5-difluoro-2-methoxyphenyl)methanone
741713-33-7

(4-amino-2-ethylsulfanylpyrimidin-5-yl)(4,5-difluoro-2-methoxyphenyl)methanone

C

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

Conditions
ConditionsYield
Stage #1: 1-bromo-4,5-difluoro-2-methoxybenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃;
Stage #2: 4-amino-2-ethylsulfanylpyrimidine-5-carboxylic acid metoxymethylamide In tetrahydrofuran; hexane at -78 - -35℃; for 2h;
trimethylaluminum
75-24-1

trimethylaluminum

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

Conditions
ConditionsYield
With hydroxylamine hydrochloride In tetrahydrofuran; toluene at 0℃; Inert atmosphere;
N-methoxy-N-methylbenzenesulfonamide

N-methoxy-N-methylbenzenesulfonamide

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

Conditions
ConditionsYield
Stage #1: N-methoxy-N-methylbenzenesulfonamide With iodine; magnesium In methanol for 0.5h; Sonication;
Stage #2: With hydrogenchloride In water pH=1;
46%
2-[3-(4-Bromo-phenyl)-benzo[d]isothiazol-6-yloxy]-N-methoxy-N-methyl-acetamide

2-[3-(4-Bromo-phenyl)-benzo[d]isothiazol-6-yloxy]-N-methoxy-N-methyl-acetamide

A

[3-(4-Bromo-phenyl)-benzo[d]isothiazol-6-yloxy]-acetic acid

[3-(4-Bromo-phenyl)-benzo[d]isothiazol-6-yloxy]-acetic acid

B

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

phenylacetic acid
103-82-2

phenylacetic acid

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

N-methoxy-N-methyl-2-phenylacetamide
95092-10-7

N-methoxy-N-methyl-2-phenylacetamide

Conditions
ConditionsYield
With diethyl cyanophosphonate; triethylamine In N,N-dimethyl-formamide 1) -10 deg C, 0.5 h, 2) r.t., 2.5 h;100%
With sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran; water at 20℃; for 3.5h; pH=4.5;100%
Stage #1: phenylacetic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran for 1h;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride With trimethylamine In tetrahydrofuran; acetonitrile for 20h;
97%
indole-3-acetic acid
87-51-4

indole-3-acetic acid

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

2-(1H-indol-3-yl)-N-methoxy-N-methyl-acetamide
132922-37-3

2-(1H-indol-3-yl)-N-methoxy-N-methyl-acetamide

Conditions
ConditionsYield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In dichloromethane; ethyl acetate at 20℃; for 1h;100%
Stage #1: indole-3-acetic acid With 1,1'-carbonyldiimidazole In dichloromethane at 0 - 20℃; for 2h; Inert atmosphere;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride In dichloromethane at 0 - 20℃; for 12h; Inert atmosphere;
97%
With triethylamine; dicyclohexyl-carbodiimide In dichloromethane for 2h; Ambient temperature;84%
t-Boc-L-valine
13734-41-3

t-Boc-L-valine

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

tert-butyl (S)-1-(N-methoxy-N-methylcarbamoyl)-2-methylpropylcarbamate
87694-52-8

tert-butyl (S)-1-(N-methoxy-N-methylcarbamoyl)-2-methylpropylcarbamate

Conditions
ConditionsYield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 4℃;100%
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃;100%
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;100%
N-(tert-butyloxycarbonyl)-L-isoleucine
13139-16-7

N-(tert-butyloxycarbonyl)-L-isoleucine

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

N-(tert-butoxycarbonyl)-L-isoleucine N'-methoxy-N'-methylamide
87694-51-7

N-(tert-butoxycarbonyl)-L-isoleucine N'-methoxy-N'-methylamide

Conditions
ConditionsYield
Stage #1: N-(tert-butyloxycarbonyl)-L-isoleucine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 0.25h; Inert atmosphere;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride With 4-methyl-morpholine In dichloromethane at 0 - 25℃; for 14h; Inert atmosphere;
100%
Stage #1: N-(tert-butyloxycarbonyl)-L-isoleucine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 0.25h; Inert atmosphere;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride With 4-methyl-morpholine In dichloromethane at 25℃; for 14h; Inert atmosphere;
100%
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 2h;91%
N-tert-butoxycarbonyl-L-leucine
13139-15-6

N-tert-butoxycarbonyl-L-leucine

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

N-(tert-butoxycarbonyl)-L-leucine-N'-methoxy-N'-methylamide
87694-50-6

N-(tert-butoxycarbonyl)-L-leucine-N'-methoxy-N'-methylamide

Conditions
ConditionsYield
Stage #1: N-tert-butoxycarbonyl-L-leucine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 0.25h; Inert atmosphere;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride With 4-methyl-morpholine In dichloromethane at 0 - 25℃; for 14h; Inert atmosphere;
100%
Stage #1: N-tert-butoxycarbonyl-L-leucine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 0.25h; Inert atmosphere;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride With 4-methyl-morpholine In dichloromethane at 25℃; for 14h; Inert atmosphere;
100%
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane100%
L-N-Boc-Ala
15761-38-3

L-N-Boc-Ala

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

tert-butyl {(S)-1-[methoxy(methyl)amino]-1-oxopropan-2-yl}carbamate
146553-06-2, 87694-49-3

tert-butyl {(S)-1-[methoxy(methyl)amino]-1-oxopropan-2-yl}carbamate

Conditions
ConditionsYield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane100%
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;100%
With 1,1'-carbonyldiimidazole In dichloromethane for 16h;99%
cyclohexanone-4-carboxylic acid ethyleneacetal
66500-55-8

cyclohexanone-4-carboxylic acid ethyleneacetal

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

N-Methoxy-N-methyl-1,4-dioxaspiro<4.5>decane-8-carboxamide

N-Methoxy-N-methyl-1,4-dioxaspiro<4.5>decane-8-carboxamide

Conditions
ConditionsYield
Stage #1: cyclohexanone-4-carboxylic acid ethyleneacetal With 1,1'-carbonyldiimidazole In dichloromethane for 1.66667h; Large scale;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride In dichloromethane for 24.25h; Large scale;
100%
With 1,1'-carbonyldiimidazole 1.) CHCl3, 2.) r.t., 18 h; Yield given. Multistep reaction;
Stage #1: cyclohexanone-4-carboxylic acid ethyleneacetal With 1,1'-carbonyldiimidazole In dichloromethane for 1.33333h;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride In dichloromethane for 24h;
N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

Nα-(t-butyloxycarbonyl)-Nω-(4-methoxy-2,3,6-trimethylbenzenesulphonyl)-L-arginine
102185-38-6

Nα-(t-butyloxycarbonyl)-Nω-(4-methoxy-2,3,6-trimethylbenzenesulphonyl)-L-arginine

N-α-(t-butyloxycarbonyl)-N'-ω'-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-L-arginine-N,O-dimethylhydroxyamide
142801-55-6

N-α-(t-butyloxycarbonyl)-N'-ω'-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-L-arginine-N,O-dimethylhydroxyamide

Conditions
ConditionsYield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 0 - 20℃; for 2h;100%
With N-ethyl-N,N-diisopropylamine; HATU In tetrahydrofuran at 20℃; for 3h; Inert atmosphere;93%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 4.5h;92%
N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

(2R)-3-(biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid
128779-47-5

(2R)-3-(biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid

(R)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-N-methoxy-N-metyl<1,1'-biphenyl>-4-propanamide
162972-36-3

(R)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-N-methoxy-N-metyl<1,1'-biphenyl>-4-propanamide

Conditions
ConditionsYield
With 2-(6-chloro-1H-benzotriazole-1-yl)21,1,3,3-tetramethylaminiumhexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane100%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane for 16h; Ambient temperature;97%
Stage #1: N,O-dimethylhydroxylamine*hydrochloride; (2R)-3-(biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid With 4-methyl-morpholine In dichloromethane at -15℃; for 0.0833333h; Inert atmosphere;
Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at -15 - 20℃; for 5.5h; Inert atmosphere;
87%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; Inert atmosphere;22.7 g
N-(fluoren-9-ylmethoxycarbonyl)glycine
29022-11-5

N-(fluoren-9-ylmethoxycarbonyl)glycine

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

(9H-fluoren-9-yl)methyl (2-(methoxy(methyl)amino)-2-oxoethyl)carbamate
156939-65-0

(9H-fluoren-9-yl)methyl (2-(methoxy(methyl)amino)-2-oxoethyl)carbamate

Conditions
ConditionsYield
With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 4h; Inert atmosphere;100%
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;98%
Stage #1: N-(fluoren-9-ylmethoxycarbonyl)glycine With trichloroacetonitrile; triphenylphosphine In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride With triethylamine In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;
89%
Boc-Nle-OH
6404-28-0

Boc-Nle-OH

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

N-Methoxy-N-methyl 2(S)-(tert-butoxycarbonylamino) hexanamide
104062-69-3

N-Methoxy-N-methyl 2(S)-(tert-butoxycarbonylamino) hexanamide

Conditions
ConditionsYield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane100%
Stage #1: Boc-Nle-OH With 4-methyl-morpholine; isobutyl chloroformate In dichloromethane at -15℃; for 0.5h;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride In dichloromethane at -15 - 20℃; for 17h;
94%
Stage #1: Boc-Nle-OH With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane for 0.25h;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride In dichloromethane at 20℃;
85%
N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

Fmoc-Lys(tert-butoxycarbonyl)
71989-26-9

Fmoc-Lys(tert-butoxycarbonyl)

(S)-N-α-(fluorenylmethyloxycarbonyl)-N-ε-(tert-butyloxycarbonyl)-lysine N-methoxy-N-methylamide
151145-21-0

(S)-N-α-(fluorenylmethyloxycarbonyl)-N-ε-(tert-butyloxycarbonyl)-lysine N-methoxy-N-methylamide

Conditions
ConditionsYield
Stage #1: Fmoc-Lys(tert-butoxycarbonyl) With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-d6-formamide at 0℃; for 0.5h;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 3.5h;
100%
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide98%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane96%
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

N-methoxy-N-methyl-2-furancarboxamide
95091-92-2

N-methoxy-N-methyl-2-furancarboxamide

Conditions
ConditionsYield
With pyridine; sodium carbonate In tetrahydrofuran at 20℃; Inert atmosphere;100%
With triethylamine In dichloromethane Ambient temperature;92%
With potassium carbonate In 2-methyltetrahydrofuran; water at 0 - 20℃;92%
3-methylthenoyl chloride
61341-26-2

3-methylthenoyl chloride

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

N-methoxy-N-methyl-3-methylthiophene-2-carboxamide
181868-50-8

N-methoxy-N-methyl-3-methylthiophene-2-carboxamide

Conditions
ConditionsYield
With triethylamine In chloroform at 0 - 20℃; Inert atmosphere;100%
With triethylamine In chloroform at 0 - 20℃;100%
With pyridine In dichloromethane for 2h; Ambient temperature; Yield given;
With triethylamine In chloroform at 0 - 20℃;28.8 g
N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

(S)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propionic acid methyl ester
95514-03-7

(S)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propionic acid methyl ester

(S)-3-(tert-butyldiphenylsilyloxy)-N-methoxy-N,2-dimethylpropanamide
185996-35-4

(S)-3-(tert-butyldiphenylsilyloxy)-N-methoxy-N,2-dimethylpropanamide

Conditions
ConditionsYield
With isopropylmagnesium chloride In tetrahydrofuran at 0℃; for 2h; Inert atmosphere;100%
With isopropylmagnesium chloride In tetrahydrofuran at -20 - -5℃;99%
With trimethylaluminum In dichloromethane; toluene for 4h; Heating;60%
N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

4-fluorobenzoyl chloride
403-43-0

4-fluorobenzoyl chloride

4-fluoro-N-methoxy-N-methylbenzamide
116332-54-8

4-fluoro-N-methoxy-N-methylbenzamide

Conditions
ConditionsYield
With triethylamine In dichloromethane for 0.5h;100%
With triethylamine In dichloromethane100%
With triethylamine In dichloromethane at 0 - 18℃; for 16.5h; Inert atmosphere;99%
3-(tert-butyloxycarbonylamino)propionic acid
3303-84-2

3-(tert-butyloxycarbonylamino)propionic acid

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

[2-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester
142570-56-7

[2-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: 3-(tert-butyloxycarbonylamino)propionic acid With 4-methyl-morpholine; isobutyl chloroformate In dichloromethane at -15℃; for 0.25h;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride In dichloromethane at -15 - 20℃; for 16h;
100%
Stage #1: 3-(tert-butyloxycarbonylamino)propionic acid With 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 0.5h;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane
99%
With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at -15 - 20℃; Inert atmosphere;95%
5-methyl-benzofuran-2-carbonyl chloride
90723-52-7

5-methyl-benzofuran-2-carbonyl chloride

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

5-Methyl-benzofuran-2-carboxylic acid methoxy-methyl-amide
194471-27-7

5-Methyl-benzofuran-2-carboxylic acid methoxy-methyl-amide

Conditions
ConditionsYield
With triethylamine In dichloromethane for 0.5h; Ambient temperature;100%
N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

Heptanoic acid chloride
2528-61-2

Heptanoic acid chloride

heptanoic acid N,O-dimethylhydroxyamide
104863-66-3

heptanoic acid N,O-dimethylhydroxyamide

Conditions
ConditionsYield
With pyridine100%
With pyridine In dichloromethane at 20℃; for 1h;93%
With TEA In dichloromethane92%
N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid
84358-13-4

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

tert-butyl 4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate
139290-70-3

tert-butyl 4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: N,O-dimethylhydroxylamine*hydrochloride; N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid With triethylamine In DMF (N,N-dimethyl-formamide) at 20℃; for 0.166667h;
Stage #2: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In DMF (N,N-dimethyl-formamide)
Stage #3: With hydrogenchloride In water
100%
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 48h;99%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;99%
N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

3-(tert-butyldimethylsilanyloxy)-4,4-dimethyldihydro-2(3H)-furan-2-one
133094-78-7

3-(tert-butyldimethylsilanyloxy)-4,4-dimethyldihydro-2(3H)-furan-2-one

(R)-2-(tert-butyldimethylsilyloxy)-4-hydroxy-N-methoxy-N,3,3-trimethylbutanamide
218434-95-8

(R)-2-(tert-butyldimethylsilyloxy)-4-hydroxy-N-methoxy-N,3,3-trimethylbutanamide

Conditions
ConditionsYield
Stage #1: N,O-dimethylhydroxylamine*hydrochloride; 3-(tert-butyldimethylsilanyloxy)-4,4-dimethyldihydro-2(3H)-furan-2-one With isopropylmagnesium chloride In tetrahydrofuran at 0℃;
Stage #2: With water In tetrahydrofuran at 0℃; pH=7; aq. phosphate buffer;
100%
With trimethylaluminum In hexane; benzene for 1h; Ambient temperature;98%
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