116332-66-2

Upstream product

• 579-75-9 2-Methoxybenzoic acid 
• 21615-34-9 2-Methoxybenzoyl chloride 
• 5757-97-1 2-Methoxy-acetophenon-(dimethyl-hydrazon) 
• 606-45-1 2-methoxybenzoic acid methyl ester 
• 121789-31-9 1-(2-Methoxyphenyl)-3-(1,3-dioxan-2-yl)-1-propanon 
• 116332-60-6 N'-[4,4-Dimethoxy-1-(2-methoxy-phenyl)-but-(E)-ylidene]-N,N-dimethyl-hydrazine 

Downstream Products

• 69640-32-0 2-(2-methoxyphenyl)pyrrole 

Relevant academic research and scientific papers

Marine Bacteria, I. - Synthesis of Pentabromopseudiline, a Cytotoxic Phenylpyrrole from Alteromonas luteo-violaceus

A new synthesis of 2,3,4-tribromo-5-(3,5-dibromo-2-hydroxyphenyl)pyrrole (1a, pentabromopseudiline), an antibiotic, enzymeinhibitory and cytotoxic active constituent of the marine bacterium Alteromonas luteo-violaceus, is described.For investigation of structure-activity relationships further 2-phenylpyrroles are investigated.Key step in their synthesis is the Grignard reaction of 2-(1,3-dioxan-2-yl)ethylmagnesium bromide (9d) with benzoyl chlorides yielding γ-phenyl-γ-ketoaldehydes 24, and the Paal-Knorr cyclisation of the latter. - Key Words: Alteromonas luteo-violaceus / Bromopyrrole / Marine bacteria / Pentabromopseudiline

NEW METHODS FOR THE SYNTHESIS OF 2-ARYLPYRROLES

Two short and efficient synthetic approaches for -mostly unknown- 2-arylpyrroles are presented.The key intermediates 3 are conveniently obtained from commercially available acetophenones 5 (method I) or benzoic acid derivatives 10, 11 (method II).