116342-26-8Relevant academic research and scientific papers
Copper-catalyzed enantioselective carbonylation toward α-chiral secondary amides
Wu, Xiao-Feng,Yuan, Yang,Zhao, Fengqian
, p. 12676 - 12681 (2021)
Secondary amides are omnipresent structural motifs in peptides, natural products, pharmaceuticals, and agrochemicals. The copper-catalyzed enantioselective hydroaminocarbonylation of alkenes described in this study provides a direct and practical approach for the construction of α-chiral secondary amides. An electrophilic amine transfer reagent possessing a 4-(dimethylamino)benzoate group was the key to the success. This method also features broad functional group tolerance and proceeds under very mild conditions, affording a set of α-chiral secondary amides in high yields (up to 96% yield) with unprecedented levels of enantioselectivity (up to >99% ee). α,β-Unsaturated secondary amides can also be produced though the method by using alkynes as the substrate.
CHIRAL-OPTICAL CHARACTERISTICS OF R-(-)-HYDRATROPANILIDES
Potapov, V. M.,Dem'yanovich, V. M.,Solov'eva, L. D.,Ivannikov, S. V.
, p. 2240 - 2245 (2007/10/02)
The significant Cotton effect in the unsubstituted and para-substituted anilides of R-(-)-hydratropic acid in the region of the absorption band for the anilide chromophore (240-250 nm) is explained by the interaction of this chromophore with the aromatic
