116346-40-8

Upstream product

• 116216-27-4 dimethyl 4-(exo-benzoyloxy)bicyclo<3.3.1>non-2-en-1-endo,7-dicarboxylate 
• 114584-45-1 (1R,3R,5S,6S)-6-Hydroxy-bicyclo[3.3.1]non-7-ene-1,3-dicarboxylic acid dimethyl ester 
• 65-85-0 benzoic acid 
• 116216-22-9 (1S,2R,5S,7R)-4-(tert-Butyl-dimethyl-silanyloxy)-tricyclo[3.3.1.0^2,7]non-3-ene-1,7-dicarboxylic acid dimethyl ester 
• 116216-25-2 (1R,3R,5S)-6-Oxo-bicyclo[3.3.1]non-7-ene-1,3-dicarboxylic acid dimethyl ester 
• 116216-23-0 (1R,2R,5S,7S)-4-Oxo-tricyclo[3.3.1.0^2,7]nonane-1,7-dicarboxylic acid dimethyl ester 
• 116216-24-1 (1S,3S,5R)-6-Oxo-bicyclo[3.3.1]non-7-ene-1,3-dicarboxylic acid 
• 114584-45-1 dimethyl 4-(endo-hydroxy)bicyclo<3.3.1>non-2-en-1-endo,7-dicarboxylate 
• 116216-22-9 1,7-bis-carbomethoxy-4-(t-butyldimethylsilyloxy)-tricyclo<3.3.1.0^2,7>non-3-ene 
• 116216-25-2 dimethyl bicyclo<3.3.1>non-2-en-4-one-1-endo,7-dicarboxylate 
• 116216-23-0 1,7-bis-carbomethoxytricyclo<3.3.1.0^2,7>nonan-4-one 
• 116216-24-1 bicyclo<3.3.1>non-2-en-4-one-1-endo,7-dicarboxylic acid 

Downstream Products

• 116216-27-4 dimethyl 4-(exo-benzoyloxy)bicyclo<3.3.1>non-2-en-1-exo,7-dicarboxylate 

Relevant academic research and scientific papers

STEREOSELECTIVE FRAGMENTATION OF A TRICYCLIC DIESTER LEADING TO A POTENT CHORISMATE MUTASE TRANSITION STATE INHIBITOR

High kinetic stereoslectivity in the base-catalyzed fragmentation of 1,7-dicarbomethoxytricyclo2,7>nonan-4-one 11 led to a convergent, high-yielding synthesis of 6.

Transition-state analogue inhibitors of chorismate mutase

The synthesis of seven bi- and tricyclic chorismate analogues 9-15 and their biological evaluation as mutase inhibitors is described. A tandem Cope rearrangement/Diels-Alder cycloaddition strategy was employed to prepare tricyclo[3.3.1.02,7]non