116359-75-2

Basic information

• Product Name: 3-methyl-1-pyridin-2-yl-1H-indole
• Synonyms: 3-methyl-1-pyridin-2-yl-1H-indole
• CAS NO: 116359-75-2
• Molecular Formula: C₁₄H₁₂N₂
• Molecular Weight: 208
• Mol File: 116359-75-2.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-methyl-1-pyridin-2-yl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-1-pyridin-2-yl-1H-indole(116359-75-2)
• EPA Substance Registry System: 3-methyl-1-pyridin-2-yl-1H-indole(116359-75-2)

Safety Data

• Hazardous Substances Data: 116359-75-2(Hazardous Substances Data)

Usage

Commonly known as

MPI

Class

Indole derivative

Molecular structure

Consists of an indole ring substituted with a methyl group and a pyridine ring

Pharmacological activities

Studied for effects on central nervous system, potential as antineoplastic agent, role in treatment of neurodegenerative diseases, potential as anti-inflammatory and antioxidant agent

Therapeutic potential

Continues to be explored for potential therapeutic applications and mechanisms of action.

Upstream product

• 83-34-1 3-Methylindole 
• 372-48-5 2-fluoropyridine 
• 5029-67-4 2-iodopyridine 
• 109-04-6 2-bromo-pyridine 
• 109-09-1 2-chloropyridine 

Downstream Products

• 1283073-92-6 3-methyl-2-phenyl-1-(pyridin-2-yl)-1H-indole 
• 1401518-62-4 2-(4-methoxyphenyl)-3-methyl-1-(pyridin-2-yl)-1H-indole 
• 1401518-63-5 2-(4-fluorophenyl)-3-methyl-1-(pyridin-2-yl)-1H-indole 

Relevant articles and documents

Cp?CoIII-Catalyzed Synthesis of Pyrido[2′,1′:2,3]pyrimido[1,6-a]indol-5-iums via Tandem C-H Activation and Subsequent Annulation from 1-(Pyridin-2-yl)-1H-indoles and Internal Alkynes

A Cp?CoIII-catalyzed C2-selective C-H alkenylation/annulation cascade transformation of 1-(pyridin-2-yl)-1H-indoles with internal alkynes to afford pyrido[2′,1′:2,3]pyrimido[1,6-a]indol-5-iums is presented. Moreover, 6,7-dihydro-4H-pyrido[2′,1′:2,3]pyrimido[1,6-a]indole, a new functionalized N-fused indole core heterocycle, could be constructed effectively via reduction of pyrido[2′,1′:2,3]pyrimido[1,6-a]indol-5-ium by NaBH4.

Rh/Cu-catalyzed multiple C-H, C-C, and C-N bond cleavage: Facile synthesis of pyrido[2,1-a]indoles from 1-(pyridin-2-yl)-1H-indoles and γ-substituted propargyl alcohols

An unusual Rh/Cu-catalyzed synthesis of pyrido[2,1-a]indoles starting from 1-(pyridin-2-yl)-1H-indoles and γ-substituted propargyl alcohols was presented. The multi-step cascade transformations formally involve the cleavage of two C-H, three C-C, and one C-N bonds with concomitant construction of two C-H, four C-C, and one C-N bonds with excellent chemoselectivity in one-pot reaction.

Nitroarenes as the Nitrogen Source in Intermolecular Palladium-Catalyzed Aryl C–H Bond Aminocarbonylation Reactions

A three-component palladium-catalyzed aminocarbonylation of aryl and heteroaryl sp2 C?H bonds using nitroarenes as the nitrogen source was achieved using Mo(CO)6 as the reductant and origin of the CO. This intermolecular C?H bond functionalization does not requires any exogenous ligand to be added, and our mechanism experiments indicate that the palladacycle catalyst serves two roles in the aminocarbonylation reaction: reduce the nitroarene to a nitrosoarene and activate the sp2 C?H bond.