1283073-92-6

Upstream product

• 109-04-6 2-bromo-pyridine 
• 673-32-5 1-Phenylprop-1-yne 
• 6631-37-4 2-(phenylamino)pyridine 
• 62-53-3 aniline 
• 83-34-1 3-Methylindole 
• 116359-75-2 3-methyl-1-(pyridine-2-yl)-1H-indole 
• 98-80-6 phenylboronic acid 
• 300-57-2 allylbenzene 

Relevant academic research and scientific papers

Rhodium(iii)-catalyzed regioselective oxidative annulation of anilines and allylbenzenes: Via C(sp3)-H/C(sp2)-H bond cleavage

Described herein is the merging of allylic C(sp3)-H activation and directed C(sp2)-H activation into a single approach for discovering unprecedented chemical transformations. As a proof-of-concept, we disclose for the first time the

Cobalt(II)-Catalyzed Oxidative C-H Arylation of Indoles and Boronic Acids

Co(II)-catalyzed C-H C2 selective arylation of indoles with boronic acids through monodentate chelation assistance has been achieved for the first time. The unique features of this methodology include mild reaction conditions, highly C2 regioselectivity, and employment of a Grignard reagent-free catalytic system. A wide range of substrates, including unreactive arenes, are well tolerated, which enables the construction of the coupling products efficiently. This new strategy provides an alternative and versatile approach to construct biaryls using inexpensive cobalt catalyst.

Ruthenium-catalyzed heteroatom-directed regioselective C-H arylation of indoles using a removable tether

A new approach to C-2 arylated indoles has been developed by utilizing a ruthenium-catalyzed, heteroatom-directed regioselective C-H arylation. The reaction is highly site-selective and results in very good yields. The highlight of the work is the use of a removable directing group and compatibility of the catalytic system with halogen functional groups in the substrates.

Nanocrystalline magnesium oxide-stabilized palladium(0): An efficient and reusable catalyst for synthesis of N-(2-pyridyl)indoles

A selective and efficient catalytic process has been developed for the oxidative coupling between N-aryl-2-aminopyridines and alkynes using a nanocrystalline magnesium oxide (NAP-MgO)-supported palladium nanoparticle [NAP-Mg-Pd(0)] catalyst and CuCl2 as an oxidant. The process involves the ortho C-H activation of N-aryl-2-aminopyridines to give N-pyridyl indoles in excellent yields and the true heterogeneity of the catalyst is verified by studying the recoverability and reusability for four cycles without significant loss of catalytic activity.

Synthesis of N-(2-pyridyl)indoles via Pd(II)-catalyzed oxidative coupling

Readily available Pd(II) chloride catalysts can catalyze selective and efficient oxidative coupling between N-aryl-2-aminopyridines and internal alkynes to yield N-(2-pyridyl)indoles. This process involves the ortho C-H activation of N-aryl-2-aminopyridines, and CuCl2 was used as an oxidant. Compared to our previously reported Rh(III)-catalyzed synthesis of this class of product, this method is advantageous with a wider scope of alkynes and cost-effective Pd(II) catalysts. Molecular oxygen can be used as a terminal oxidant.