116366-79-1Relevant academic research and scientific papers
Facile entry to 4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyrazin-6-ones from amines and amino acids
Sai Sudhir,Nasir Baig,Chandrasekaran, Srinivasan
scheme or table, p. 2423 - 2429 (2009/04/06)
A practical and high-yielding regioselective synthesis of several enantiopure 4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]-pyrazin-6-ones is described starting from primary amines and α-amino acid derivatives in a three-step reaction sequence by employing a constrained intramolecular "click" reaction as the key step. The method obviates chromatographic purification of products. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
Kinetic acidity of iminium ions. 2-Alkynyl- and 2,5-dialkynyl-pyrrolidines via the iminium ion route to azomethine ylides
Grigg, Ronald,Sridharan, Visuvanathar,Thornton-Pett, Mark,Wang, Jun,Xu, Juan,Zhang, Jin
, p. 2627 - 2640 (2007/10/03)
Condensation of carboxaldehydes with appropriate secondary propargylamines furnishes iminium ions which undergo regioselective deprotonation at the propargylic methylene group to generate azomethine ylides. Interception of the latter by N-methyl or N-phenyl maleimide furnishes 2- and 2,5-dialkynyl-pyrrolidines.
