1163689-90-4

Upstream product

• 147444-03-9 α-pyronemeroterpenoid pyripyropene A 
• 1163689-88-0 7-O-p-cyanobenzoyl-1,11-O-(di-tert-butylsilylene)-1,7,11-trideacetylpyripyropene A 
• 619-65-8 4-cyanobenzoic Acid 

Downstream Products

• 1338330-88-3 7-O-p-cyanobenzoyl-1,11-O-dibenzoyl-1,7,11-trideacetyl-pyripyropene A 
• 1338330-90-7 7-O-p-cyanobenzoyl-1,11-O-dihexanoyl-1,7,11-trideacetyl-pyripyropene A 

Relevant academic research and scientific papers

Regioselective mono-deprotection of di-ferf-butylsilylene acetal derived from 1,3-diol with ammonium fluoride

Here we report a novel and efficient method for the regioselective mono-deprotection of di-terf-butylsilylene acetals derived from 1,3-diols consisting of primary and secondary alcohols. The ammonium fluoride-mediated reactions of pyripyropene A derivative, thymidine and uridine derivatives, methyl β-D-glucofuranoside, and pyranoside derivatives each gave the corresponding primary alcohol with high regioselectivity.

PYRIPYROPENE DERIVATIVE HAVING ACAT2 INHIBITING ACTIVITY AND STABLE TO METABOLIZING ENZYMES

A compound effective in prevention and treatment of arteriosclerosis with a mechanism different from that of statin drugs has the following formula or a pharmaceutically acceptable salt, solvate, or hydrate thereof: wherein R1 is an aliphatic, alicyclic, or aromatic acyloxy group, or a group of the formula -O-CH(R7)-R8 where R7 is a lower alkoxy group and R8 is an aryl group, and R2 is carboxyl, a lower alkoxycarbonyl group, or an arylmethylcarbamoyl group, or a -CH2-acyloxy group and R3 is an aliphatic, alicyclic or aromatic acyloxy group, provided that at least one of R4 and R3 is a group other than acetoxy, or R2 and R3 taken together form a group of the formula -O-CH(R5)-O- where R5 is an aryl group.