1163700-92-2

Upstream product

• 696-62-8 para-iodoanisole 
• 466639-53-2 3-bromo-4-iodoanisole 
• 768-60-5 4-methoxyphenylacetylen 

Downstream Products

• 176672-06-3 3-bromo-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene 
• 1163701-10-7 (5-methoxy-2-((4-methoxyphenyl)ethynyl)phenyl)(methyl)-sulfane 
• 264142-55-4 3-iodo-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene 
• 1163701-90-3 C₂₇H₂₆O₄S 
• 1261352-31-1 C₂₂H₁₈O₃S 

Relevant academic research and scientific papers

Synthesis of a 3-(α-Styryl)benzo[ b ]-thiophene Library via Bromocyclization of Alkynes and Palladium-Catalyzed Tosylhydrazones Cross-Couplings: Evaluation as Antitubulin Agents

A library of functionalized 3-(α-styryl)-benzo[b]thiophenes, endowed with a high level of molecular diversity, was efficiently synthesized by applying a synthetic sequence that allowed introduction of various substituents on aromatic A, B, and C-rings. Th

Parallel synthesis of a desketoraloxifene analogue library via iodocyclization/palladium-catalyzed coupling

For a future structure-activity relationship (SAR) study, a library of desketoraloxifene analogues has been prepared by parallel synthesis using iodocyclization and subsequent palladium-catalyzed coupling reactions. Points of desketoraloxifene diversification involve the two phenolic hydroxyl groups and the aliphatic amine side chain. This approach affords oxygen-bearing 3-iodobenzo[b]thiophenes 4 in excellent yields, which are easily further elaborated using a two-step approach involving Suzuki-Miyaura and Mitsunobu coupling reactions to give multimethoxy-substituted desketoraloxifene analogues 6. Various hydroxyl-substituted desketoraloxifene analogues 7 were subsequently generated by demethylation with BBr3.