264142-55-4

Upstream product

• 768-60-5 4-methoxyphenylacetylen 
• 1163700-92-2 2-bromo-4-methoxy-1-((4-methoxyphenyl)ethynyl)benzene 
• 466639-53-2 3-bromo-4-iodoanisole 
• 1163701-10-7 (5-methoxy-2-((4-methoxyphenyl)ethynyl)phenyl)(methyl)-sulfane 
• 334708-19-9 benzyl 2-iodo-5-methoxyphenyl sulfide 
• 874903-81-8 dithiocarbonic acid O-ethyl ester S-(2-iodo-5-methoxyphenyl) 
• 153898-63-6 2-iodo-5-methoxyaniline 
• 60512-57-4 1-(2,2-dibromovinyl)-4-methoxybenzene 
• 1025928-71-5 2-Benzylsulfanyl-4-methoxy-1-(4-methoxy-phenylethynyl)-benzene 

Downstream Products

• 1261352-31-1 C₂₂H₁₈O₃S 
• 1163701-90-3 C₂₇H₂₆O₄S 
• 63675-87-6 [6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl](4-methoxy-phenyl)-methanone 

Relevant academic research and scientific papers

Oxone-mediated halocyclization/demethylation of 2-alkynylthioanisoles with sodium halides towards 3-halobenzo[b]thiophenes

An efficient and practical protocol for the Oxone-mediated halocyclization/demethylation of 2-alkynylthioanisoles towards valuable 3-halobenzo[b]thiophenes is described. Structurally diverse 3-halobenzothiophenes were obtained in good to excellent yields

Parallel synthesis of a desketoraloxifene analogue library via iodocyclization/palladium-catalyzed coupling

For a future structure-activity relationship (SAR) study, a library of desketoraloxifene analogues has been prepared by parallel synthesis using iodocyclization and subsequent palladium-catalyzed coupling reactions. Points of desketoraloxifene diversification involve the two phenolic hydroxyl groups and the aliphatic amine side chain. This approach affords oxygen-bearing 3-iodobenzo[b]thiophenes 4 in excellent yields, which are easily further elaborated using a two-step approach involving Suzuki-Miyaura and Mitsunobu coupling reactions to give multimethoxy-substituted desketoraloxifene analogues 6. Various hydroxyl-substituted desketoraloxifene analogues 7 were subsequently generated by demethylation with BBr3.

A new approach to desketoraloxifene analogs from oxygen-bearing 3-iodobenzo[b]thiophenes prepared via iodocyclization

A formal total synthesis of the benzothiophene selective estrogen receptor modulator (SERM) desketoraloxifene and analogs has been accomplished from alkynes bearing electron-rich aromatic rings by electrophilic cyclization using I2. This approa

A novel palladium-mediated coupling approach to 2,3-disubstituted benzo[b]thiophenes and its application to the synthesis of tubulin binding agents

Flexible, convergent access to 2,3-disubstituted benzo[b]thiophenes has been developed. The most concise approach involves sequential coupling of o-bromoiodobenzenes with benzylmercaptan and zinc acetylides to give benzyl o-ethynylpnenyl sulfides which re