116376-77-3Relevant academic research and scientific papers
Effect of structure on potency and selectivity in 2,6-disubstituted 4-(2-arylethenyl)phenol lipoxygenase inhibitors
Lazer,Wong,Wegner,Graham,Farina
, p. 1892 - 1898 (2007/10/02)
A series of 2,6-disubstituted 4-(2-arylethenyl)phenols with potent human neutrophil 5-lipoxygenase (5-LO) inhibiting activity (IC50s in the 10-7 M range) and weaker human platelet cyclooxygenase (CO) inhibiting activity (IC50/s
Antiinflammatory 2,6-Di-tert-butyl-4-(2-arylethenyl)phenols
Lazer, Edward S.,Wong, Hin-Chor,Possanza, Genus J.,Graham, Anne G.,Farina, Peter R.
, p. 100 - 104 (2007/10/02)
A series of 2,6-di-tert-butyl-4-(2-arylethenyl)phenols was prepared and examined for their ability to inhibit cyclooxygenase and 5-lipoxygenase in vitro and developing adjuvant arthritis in vivo in the rat.Structure-activity relationships are discussed.Am
