501-81-5

Basic information

• Product Name: 3-Pyridylacetic acid
• Synonyms: RARECHEM AL BO 0218;TIMTEC-BB SBB005848;PYRIDYL-3-ACETIC ACID;PYRIDINE-3-ACETIC ACID;PYRIDIN-3-YL-ACETIC ACID;2-(3-PYRIDYL)ACETIC ACID;3-PYRIDYLACETIC ACID;3-PYRIDINEACETIC ACID
• CAS NO: 501-81-5
• Molecular Formula: C₇H₇NO₂
• Molecular Weight: 137.14
• EINECS: 207-928-7
• Product Categories: Organic acids;Pyridines;Heterocycle-Pyridine series
• Mol File: 501-81-5.mol
• Article Data: 11

Chemical Properties

• Melting Point: 144-146°C
• Boiling Point: 301.6 °C at 760 mmHg
• Flash Point: 136.2 °C
• Appearance: /
• Density: 1.245 g/cm³
• Vapor Pressure: 0.000463mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 3.59±0.10(Predicted)
• CAS DataBase Reference: 3-Pyridylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridylacetic acid(501-81-5)
• EPA Substance Registry System: 3-Pyridylacetic acid(501-81-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-36
• Hazardous Substances Data: 501-81-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Pyridylacetic acid is used as an intermediate compound for the synthesis of various pharmaceuticals, particularly those targeting the central nervous system. Its unique chemical structure allows it to interact with specific receptors, making it a valuable building block for the development of new drugs.
Used in Chemical Research:
In the field of chemical research, 3-Pyridylacetic acid serves as a key component in the study of nicotine and tobacco alkaloids metabolism. Its role in understanding the biological pathways and effects of these substances contributes to the development of potential therapeutic strategies and addiction treatments.
Used in Analytical Chemistry:
3-Pyridylacetic acid is utilized as a derivatizing agent in analytical chemistry, particularly for the detection and quantification of amines and other nitrogen-containing compounds. Its reactivity with these compounds allows for improved sensitivity and selectivity in analytical techniques, such as gas chromatography and mass spectrometry.
Used in Material Science:
In material science, 3-Pyridylacetic acid can be employed as a building block for the development of novel materials with specific properties, such as conductivity or magnetism. Its unique chemical structure can be exploited to create new polymers, coordination complexes, or other advanced materials with potential applications in various industries.

InChI:InChI=1/C7H7NO2.ClH/c9-7(10)4-6-2-1-3-8-5-6;/h1-3,5H,4H2,(H,9,10);1H

Upstream product

• 54401-85-3 pyridin-4-yl-acetic acid ethyl ester 
• 201230-82-2 carbon monoxide 
• 4916-55-6 3-(bromomethyl)pyridine hydrobromide 
• 6419-36-9 3-pyridineacetic acid hydrochloride 
• 81335-71-9 methyl 3-(chloroformyl)pyridine-2-carboxylate 
• 350-03-8 methyl-3-pyridylketone 
• 626-55-1 3-Bromopyridine 
• 166411-28-5 [3]pyridyl-acetic acid propyl ester 
• 166411-29-6 [3]pyridyl-acetic acid isopropyl ester 
• 69713-27-5 (pyridin-3-yl)acetic acid tert-butyl ester 
• 6443-85-2 3-pyridinylacetonitrile 
• 5423-64-3 (pyridin-3-yl)thioacetmorpholide 
• 490-75-5 Homoquinolinic acid 
• 39931-77-6 pyridin-3-yl-acetic acid ethyl ester 

Downstream Products

• 844-01-9 7-methoxy-4-methyl-3-pyridin-3-yl-2H-chromen-2-one 
• 67210-69-9 7-hydroxy-4-phenyl-3-pyridin-3-yl-chromen-2-one 
• 67210-67-7 5,7-Diacetoxy-3-(3-pyridyl)-cumarin 
• 92579-44-7 N-phenethyl-2-pyridin-3-yl-acetamide 
• 116174-35-7 5-(4-methylthiophenyl)-1-(3-pyridinyl)-2-pentanone 
• 6419-36-9 3-pyridineacetic acid hydrochloride 
• 320774-17-2 N-(2-iodophenyl)-2-(4-pyridinyl)acetamide 
• 1061377-28-3 N-(3-(3-morpholinopropoxy)phenyl)-2-(pyridin-3-yl)acetamide 
• 1246966-02-8 2-[2-(4-chloro-2-fluorophenyl)acetylamino]-6-(2-pyridin-3-ylacetyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid amide 
• 1265681-79-5 C₃₆H₃₄N₈O₂ 
• 105462-24-6 risedronic acid 
• 500-22-1 3-pyridinecarboxaldehyde 

Relevant articles and documents

Pyridineacetamide derivative serving as CDK inhibitor, and preparation method and application thereof

The invention belongs to the technical field of pyridineacetamide derivatives, and particularly relates to a pyridineacetamide derivative serving as a CDK inhibitor and a preparation method and application of the pyridine acetamide derivative. The pyridineacetamide derivative shows excellent CDK9/CDK7 enzyme inhibitory activity, and can be used for preparing drugs used for treating cancers, especially hematologic cancers including acute myeloid leukemia, multiple myeloma, chronic lymphocytic leukemia, follicular lymphoma and the like and solid tumors such as breast cancer, prostate cancer, ovarian cancer, hepatocellular carcinoma, pancreatic cancer, kidney cancer, stomach cancer, colorectal cancer, lung cancer and the like.

Pd(OH)2/C, a Practical and Efficient Catalyst for the Carboxylation of Benzylic Bromides with Carbon Monoxide

A simple, efficient, cheap, and broadly applicable system for the carboxylation of benzylic bromides with carbon monoxide and water is reported. Upon simple reaction with only 2.5 wt % of Pearlman's catalyst and 10 mol % of tetrabutylammonium bromide in tetrahydrofuran at 110 °C for 4 h, a range of benzylic bromides can be smoothly converted to the corresponding arylacetic acids in good to excellent yields after simple extraction and acid-base wash. The reaction was found to be broadly applicable, scalable, and could be successfully extended to the use of ex situ-generated carbon monoxide and applied to the synthesis of the nonsteroidal anti-inflammatory drug diclofenac.

PYRAZOLONAPHTHYRIDINE DERIVATIVE

The target is to provide PDE IV inhibitors which have a highly potent anti-asthmatic and/or COPD-prophylactic/therapeutic profile with unexpectedly excellent safety. A compound of the formula (1): wherein A is phenyl, pyridyl, 1-oxypyridyl, or thienyl, which may be unsubstituted or optionally substituted with one or more members selected from the group consisting of hydroxyl, halogen, cyano, nitro, lower alkyl, lower alkoxy, lower alkylcarbonyloxy, amino, carboxyl, lower alkoxycarbonyl, carboxy-lower alkylene, lower alkoxycarbonyl-lower alkylene, lower alkylsulfonyl, lower alkylsulfonylamino, and ureido; R1 is a group selected from the group consisting of hydrogen, hydroxyl, halogen, cyano, nitro, lower alkoxy, amino, carboxyl, and lower alkoxycarbonyl; R2 is hydrogen or lower alkyl; and m is an integer of 1 to 3; or a pharmaceutically acceptable salt thereof, possesses highly excellent PDE IV-specific inhibitory actions and is useful as an anti-asthmatic drug and/or a prophylactic/therapeutic drug for COPD with high safety.

Neuropeptide Y antagonists

The compound is a neuropeptide Y antagonist and is effective in treating feeding disorders, cardiovascular diseases and other physiological disorders.

Tricyclic compounds

Novel compounds of Formula STR1 are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the formula to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.

Carbonyl piperazinyl and piperidinyl compounds

Novel carbonyl piperazinyl and piperidinyl compounds and pharmaceutical compositions are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel carbonyl piperazinyl or piperidinyl compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.

Enhancement of the enantioselectivity of penicillin G acylase from E. coli by 'substrate tuning'

The efficiency of penicillin G acylase catalyzed transformations is enhanced significantly with respect to reaction velocity, and in particular, stereoselectivity by appropriate 'substrate tuning', i.e. by the introduction of a nitrogen atom into the part of the substrates which is recognized by the enzyme.

Substituted 2,6-substituted pyridine herbicides

Substituted pyridines having at the 3 or 5 position a carbonyl oxy(thio)ester or a heterocyclocarbonyl and at the other a substituted alkyl group, herbicidal compositions and methods of use thereof.

GAS-PHASE REPLACEMENT ?0 SUBSTITUENT CONSTANTS OF HETEROARYL GROUPS

Hammett replacement ?0 substituent constants of pyridyl, thienyl, and furyl groups are reported for the first time from gas-phase eliminations of their t-butyl and isopropyl heteroarylcarboxylate esters.

Structural and Solvent Effects on Alkaline Hydrolysis of Heterocyclic Esters

Alkaline hydrolysis of the three isomeric ethyl pyridine-carboxylates (I-III), ethyl pyridine-2-acetate (IV), ethyl pyridine-3-acetate (V), ethyl pyrazine-carboxylate (VI), ethyl furan-2-carboxylate (VII) and ethyl thiophen-2-carboxylate (VIII), have been investigated in ethanol-water and DMSO-water media.The structural effects on the hydrolysis of I-III have been discussed in terms of aza sigma values.The studies clearly show that the assumption of treating ring nitrogen as a ring substituent is truly valid.Structural effects vis-a-vis solvent effects on the hydrolysis of IV and V are discussed in detail.Application of Laidler-Landskroener equation to the alkaline hydrolysis of these esters in aq. ethanol is found to give normal values for the radius of the transition state.