116400-75-0

Upstream product

• 22591-15-7 2-(naphthalen-1-yl)cyclohexanone 
• 286-20-4 cyclohexane-1,2-epoxide 
• 14474-59-0 naphthalen-1-yl-lithium 
• 703-55-9 1-naphthylmagnesiumbromide 
• 90-11-9 1-Bromonaphthalene 
• 40358-51-8 1-cyclohex-1-enyl-naphthalene 

Downstream Products

• 157604-38-1 (1S,2R)-trans-2-(1-naphthyl)-1-cyclohexanol 
• 40358-51-8 1-cyclohex-1-enyl-naphthalene 
• 146744-37-8 (1R,2S)-trans-2-(α-naphthalenyl)cyclohexan-1-ol 
• 171868-66-9 (1R,2S)-2-(1-naphthyl)cyclohexan-1-yl acetate 
• 22591-15-7 2-(naphthalen-1-yl)cyclohexanone 
• 643760-73-0 (-)-2-(naphthalen-1-yl)cyclohexanone 
• 190256-76-9 (R)-2-(1-naphthyl)cyclohexanone 
• 1253693-60-5 1-naphthyl-1-(trimethylsiloxy)cyclohex-1-ene 

Relevant academic research and scientific papers

Preparation of Enantiomerically Pure trans- and cis-2-(1-Naphthyl)cyclohexan-1-ols

Lipase-mediated treatment of racemic trans-2-(1-naphthyl)cyclohexan-1-ol with vinyl acetate allows clear-cut enantiospecific kinetic acetylation to give (+)-(1R,2S)-acetate in excellent chemical and enantiomeric excesses leaving (+)-(1S,2R)-alcohol in an

Palladium-catalyzed asymmetric hydrogenation of 2-aryl cyclic ketones for the synthesis oftranscycloalkanols through dynamic kinetic resolution under acidic conditions

The first efficient palladium-catalyzed asymmetric hydrogenation of 2-aryl cyclic ketones has been described through dynamic kinetic resolution under acidic conditions, providing a facile access to chiraltranscycloalkanol derivatives with excellent enantioselectivities.

Lewis acid-mediated selective chlorinations of silyl enolate

A new method involving efficient, widely applicable, and highly selective α-chlorination of simple silyl enolate with Lewis acid and an α,α-dichloro-1,3-dicarbonyl controller unit was reported. Diastereoselectivity and enantioselectivity of the reaction were investigated. High reactivity and selectivity were achieved by using α,α-dichlorinated malonic ester. Copyright

Asymmetric hydrogenation of 2-arylated cycloalkanones through dynamic kinetic resolution

Asymmetric hydrogenation of 2-arylcycloalkanones with trans-RuCl 2(binap)(1,2-diamine) and t-C4H9OK in 2-propanol selectively gives the corresponding cis-2-arylcycloalkanols in excellent enantiomeric purity and high yield.

The stereochemistry of hippurate alkylation

Alkylation of the hippurate esters of trans 2-(p-substituted phenyl)cyclohexanol with benzyl bromide affords phenylalanine derivatives in high chemical yield. The reaction stereoselectivity varies from 20 to >98% depending on the aromatic group in the cyclohexyl auxiliary. A model that correctly predicts the sense of the induction is proposed.

Enzymatic resolution of trans-2-arylcyclohexan-1-ols using crude chicken liver esterase (CCLE) as biocatalyst

Homochiral trans-2-arylcyclohexan-1-ols were synthesized via crude chicken liver esterase (CCLE) mediated enantioselective hydrolysis of the corresponding racemic acetates.

Enantioselective synthesis using crude enzymes

Chiral trans-2-aryloxycyclohexan-1-ols, trans-2-alkoxycyclohexan-1-ols, trans-2-arylcyclohexan-1-ols, homoallyl alcohols, 1-aryl-1-alkanols, 1,2-diphenylethane-1,2-diol are prepared in high optical purities via enantioselective hydrolysis of acetates of the corresponding racemic alcohols using crude enzymes such as pig liver acetone powder (PLAP), goat liver acetone powder (GLAP), chicken liver acetone powder (CLAP) and bovine liver acetone powder (BLAP).