116409-29-1

Basic information

• Product Name: 6-[pyrrolidin-1-yl(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol
• Synonyms: 6-(1-Pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl)-1,3-benzodioxol-5-ol
• CAS NO: 116409-29-1
• Molecular Formula: C₂₁H₂₅NO₆
• Molecular Weight: 387.4263
• Mol File: 116409-29-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 515.2°C at 760 mmHg
• Flash Point: 265.4°C
• Density: 1.276g/cm³
• Vapor Pressure: 3.09E-11mmHg at 25°C
• Refractive Index: 1.598
• CAS DataBase Reference: 6-[pyrrolidin-1-yl(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 6-[pyrrolidin-1-yl(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol(116409-29-1)
• EPA Substance Registry System: 6-[pyrrolidin-1-yl(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol(116409-29-1)

Safety Data

• Hazardous Substances Data: 116409-29-1(Hazardous Substances Data)

Upstream product

• 123-75-1 pyrrolidine 
• 533-31-3 Sesamol 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 

Downstream Products

• 116409-01-9 6-Hydroxy-6-methyl-8-(3,4,5-trimethoxy-phenyl)-7,8-dihydro-6H-[1,3]dioxolo[4,5-g]chromene-7-carboxylic acid ethyl ester 
• 126935-04-4 10-(3,4,5-Trimethoxy-phenyl)-6,7,8,10-tetrahydro-1,3,5-trioxa-cyclopenta[b]anthracen-9-one 
• 126935-08-8 (9aR,10R)-5a-Hydroxy-10-(3,4,5-trimethoxy-phenyl)-5a,6,7,8,9a,10-hexahydro-1,3,5-trioxa-cyclopenta[b]anthracen-9-one 
• 126935-06-6 7,7-Dimethyl-10-(3,4,5-trimethoxy-phenyl)-6,7,8,10-tetrahydro-1,3,5-trioxa-cyclopenta[b]anthracen-9-one 
• 126935-07-7 (9aS,10S)-5a-Hydroxy-7,7-dimethyl-10-(3,4,5-trimethoxy-phenyl)-5a,6,7,8,9a,10-hexahydro-1,3,5-trioxa-cyclopenta[b]anthracen-9-one 
• 116409-06-4 1-[(8aR,9S)-9-(3,4,5-Trimethoxy-phenyl)-7,8,8a,9-tetrahydro-6H-1,3,5-trioxa-dicyclopenta[b,g]naphthalen-5a-yl]-pyrrolidine 
• 117211-88-8 1-[(7R,8R)-6-Methoxy-6-methyl-8-(3,4,5-trimethoxy-phenyl)-7,8-dihydro-6H-[1,3]dioxolo[4,5-g]chromen-7-yl]-ethanone 
• 126935-11-3 7-Acetyl-8-(3,4,5-trimethoxy-phenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]chromen-6-one 
• 117233-19-9 7-acetyl-6-methyl-8-(3,4,5-trimethoxyphenyl)-8H-1,3-dioxolo<4,5-g><1>benzopyran 
• 126934-98-3 4-(6-Methoxy-benzo[1,3]dioxol-5-yl)-4-(3,4,5-trimethoxy-phenyl)-butan-2-one 
• 117211-85-5 7-acetyl-7,8-dihydro-6-methyl-8-(3,4,5-trimethoxyphenyl)-6H-1,3-dioxolo<4,5-g><1>benzopyran-6-ol 
• 126934-97-2 Acetic acid 6-[3-oxo-1-(3,4,5-trimethoxy-phenyl)-butyl]-benzo[1,3]dioxol-5-yl ester 
• 116409-04-2 1-[(7S,8R)-7-Methyl-8-(3,4,5-trimethoxy-phenyl)-7,8-dihydro-6H-[1,3]dioxolo[4,5-g]chromen-6-yl]-pyrrolidine 
• 116409-20-2 1-<7,8-dihydro-6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-6H-1,3-dioxolo<4,5-g><1>benzopyran-6-yl>pyrrolidine 

Relevant articles and documents

2-(aryl (azacycloalkane-1-yl) methyl) phenol derivatives and uses thereof

The invention discloses 2-(aryl (azacycloalkane-1-yl) methyl) phenol derivatives and application thereof, and belongs to the technical field of medicines. The invention provides a compound shown in a formula I or pharmaceutically acceptable salt thereof. The series of compounds have good inhibitory activity on the histone demethylase KDM4 family in vitro, the median inhibitory concentration (IC50) of most molecules on KDM4D is less than 500 nM, and the compounds have good inhibitory effect on proliferation of various human tumor cell strains in vitro, so that the series of compounds provide a new effective choice for developing targeted histone demethylase KDM4D drugs and preparing drugs for treating and/or preventing cancers and reproductive system diseases, and have good application prospects.