1164268-75-0Relevant academic research and scientific papers
Synthesis and SAR studies of novel benzodiazepinedione-based inhibitors of Clostridium difficile (C. difficile) toxin B (TcdB)
Letourneau, Jeffrey J.,Stroke, Ilana L.,Hilbert, David W.,Cole, Andrew G.,Sturzenbecker, Laurie J.,Marinelli, Brett A.,Quintero, Jorge G.,Sabalski, Joan,Li, Yanfang,Ma, Linh,Pechik, Igor,Stein, Philip D.,Webb, Maria L.
, p. 3601 - 3605 (2018/11/10)
Synthesis and structure-activity relationships (SAR) of a novel series of benzodiazepinedione-based inhibitors of Clostridium difficile toxin B (TcdB) are described. Compounds demonstrating low nanomolar affinity for TcdB, and which possess improved stability in mouse plasma vs. earlier compounds from this series, have been identified. Optimized compound 11d demonstrates a good pharmacokinetic (PK) profile in mouse and hamster and is efficacious in a hamster survival model of Clostridium difficile infection.
ISOTHIAZOLINE DERIVATIVES AS INSECTICIDAL COMPOUNDS
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, (2013/03/28)
The present invention provides compounds of formula (I) wherein P is P0, heterocyclyl or heterocyclyl substituted by one to five Z formula (II); Y1, Y2, Y3 and Y4 are independently of each other C-H, C-R5/
INSECTICIDAL COMPOUNDS
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Page/Page column 52-53, (2009/07/25)
A compound of formula (I), wherein A1, A2, A3, A4, G1, L, R1, R2, R3, R4, Y1, Y2 and Y3 are as defined in claim 1; or a sal
