116428-95-6Relevant articles and documents
Efficient methods for the preparation of acetylenic ketones
Verkruijsse, H. D.,Heus-Kloos, Y. A.,Brandsma, I.
, p. 289 - 294 (1988)
A number of acetylenic ketones RCCC(=O)R' have been obtained in good yields from lithiated acetylenes RCCLi and acetic anhydride, N,N-dimethylacetamide, or N,N-dimethylbenzamide.The most convenient and general method consists of treating alkynylzinc chlorides with acid halides R'C(=O)Cl.Benzoyl chloride (R'=Ph), acryloyl chloride (R'=CH2=CH) and butynoyl chloride (R'=C2H5CC) react only in the presence of a catalytic amount of Pd4.