1164441-01-3Relevant academic research and scientific papers
Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs
Camps, Pelayo,Duque, Maria D.,Vazquez, Santiago,Naesens, Lieve,Clercq, Erik De,Sureda, Francesc X.,Lopez-Querol, Marta,Camins, Antoni,Pallas, Merce,Prathalingam, S. Radhika,Kelly, John M.,Romero, Vanessa,Ivorra, Dolores,Cortes, Diego
experimental part, p. 9925 - 9936 (2009/04/10)
The synthesis of several (3-noradamantyl)amines, [(3-noradamantyl)methyl]amines, (3,7-dimethyl-1-bisnoradamantyl)amines, and [(3,7-dimethyl-1-bisnoradamantyl)methyl]amines is reported. They were evaluated against a wide range of viruses and one of them inhibited the cytopathicity of influenza A virus at a concentration similar to that of amantadine. Several of the new polycyclic amines show an interesting activity as NMDA receptor antagonists. A rimantadine analogue displayed significant trypanocidal activity. Moreover, to further characterize the pharmacology of these compounds, their effects on dopamine uptake were also assessed.
