1164475-59-5Relevant academic research and scientific papers
Homocamptothecin norcantharidinate derivative, and regioselective synthesis method thereof
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Paragraph 0025; 0030-0031, (2019/11/21)
The invention provides a homocamptothecin norcantharidinate derivative I and a regioselective synthesis method thereof in the fields of design and synthesis of novel drugs. The homocamptothecin norcantharidinate derivative I has a structural formula as shown in a formula I which is described in the specification. In the formula I, R is selected from the group consisting of C1-C6 alkyl, substitutedalkyl and cycloalkyl groups. Activity test results prove that the homocamptothecin norcantharidinate derivative I designed and synthesized by using the method provided by the invention has good antitumor effect, and specifically has high activity on liver cancer, gastric cancer, colon cancer and pancreatic cancer. In addition, the method for preparing the homocamptothecin norcantharidinate derivative I provided by the invention has the advantages of easily-available raw materials, low cost, extremely-high synthesis reaction regioselectivity and high target product yield; and the homocamptothecin norcantharidinate derivative I provided by the invention is easy to be prepared.
Norcantharidin monomer-acid monoester derivative and anti-tumor application thereof
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Paragraph 0031; 0032, (2017/07/19)
The invention provides a norcantharidin monomer-acid monoester derivative and an application thereof. The structural formula of the derivative is shown as the No.3 formula (please see the specification), wherein R is selected from alkyl or benzyl of C1 to C3. An activity test proves that the third designed and synthesized norcantharidin monomer-acid monoester derivative has good inhabitation activity in liver cancer tumor cells, stomach cancer tumor cells and colon cancer tumor cells, and can be expected to be applied to preparing medicine for resisting the three tumors.
Anhydride modified cantharidin analogues useful in the treatment of cancer
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Page/Page column 5-6, (2008/06/13)
Anhydride modified cantharidin analogues useful in the treatment of certain forms of cancer also methods for the screening for anti-cancer activity of these analogues and/or their ability to sensitise cancer cells to cancer treatment. The modified cantharidin analogues have structure (I) or (II), wherein R1, R2, R3 and R4 are H, aryl or alkyl; X is O, N or S; Y is O, S, NH, NR; R is alkyl or aryl; A and B are H or CH3; W and Z are CHOH or C=O. These compounds inhibit protein phosphatase. 1
