116468-85-0Relevant academic research and scientific papers
Deracemization by enantioselective dehydrohalogenation. Synthesis of optically active compounds bearing a chiral axis.
Duhamel, L.,Ravard, A.,Plaquevent, J. C.,Ple, G.,Davoust, D.
, p. 787 - 797 (2007/10/02)
This work describes the deracemization of 4-tert-butyl and 4-methylcyclohexylidene acetic acids bearing a chiral axis.Enantioselective dehydrohalogenation of prochiral species by chiral lithium amides allowed us to obtain e.e. as high as 82percent.A mecha
ENANTIOSELECTIVE DEHYDROHALOGENATION VIA ASYMMETRIC DEPROTONATION BY CHIRAL LITHIUM AMIDES: DERACEMIZATION OF A COMPOUND BEARING A CHIRAL AXIS
Duhamel, Lucette,Ravard, Alain,Plaquevent, Jean-Christophe,Davoust, Daniel
, p. 5517 - 5520 (2007/10/02)
Chiral lithium amides exert asymmetric induction in dehydrohalogenation reactions leading to axially dissymmetric compounds.Thus the deracemization of 4-tert-butyl-cyclohexylidene acetic acid 1 via the prochiral hydrochlorinated intermediate 2 is reported
