13733-51-2

Usage

Uses

Used in Organic Synthesis:
(4-tert-butylcyclohexylidene)acetic acid is utilized as a precursor in organic synthesis, playing a crucial role in the creation of other related compounds. Its unique structural features contribute to its effectiveness in this application.
Used in Pharmaceutical Industry:
Within the pharmaceutical sector, (4-tert-butylcyclohexylidene)acetic acid is used as a reagent for the preparation of various compounds. Its potential biological activities and unique structure make it a valuable asset in the development of new drugs and treatments.
Used in Agrochemical Industry:
(4-tert-butylcyclohexylidene)acetic acid also holds potential in the agrochemical industry, where it can be employed in the development of new products. Its specific structural attributes and possible biological activities may contribute to the creation of innovative solutions for agricultural challenges.
Further Research:
While (4-tert-butylcyclohexylidene)acetic acid shows promise in these areas, additional research is necessary to fully comprehend its properties and potential uses. This will enable a more comprehensive understanding of its capabilities and facilitate its integration into various industries.

Upstream product

• 129518-99-6 ethyl (4-tert-butylcyclohexylidene)acetate 
• 98-53-3 4-tercbutyl-cyclohexanone 
• 13278-24-5 acide hydroxy-1 tertiobutyl-4 cyclohexane-acetique 
• 116468-85-0 cis 1-chloro-4-tert-butylcyclohexyl acetic acid 
• 28835-96-3 (4-tert-butylcyclohexylidene)acetic acid 
• 116468-86-1 cis 1-bromo-4-tert-butylcyclohexyl acetic acid 
• 123992-62-1 ethyl (ξ-acetoxy-4β-tert-butyl-1-cyclohexyl)acetate 
• 54280-91-0 1-<(ethoxycarbonyl)methyl>-4-tert-butylcyclohexanol 

Downstream Products

• 85164-98-3 C-((1R,4aS,10aR)-7-Isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-1-yl)-methylamine; compound with (4-tert-butyl-cyclohexylidene)-acetic acid 
• 110840-33-0 1-Allylidene-4-tert-butyl-cyclohexane 
• 110840-33-0 (aR)-(+)-(4-tert-butylcyclohexylidene)propene 
• 116468-85-0 cis 1-chloro-4-tert-butylcyclohexyl acetic acid 
• 116468-86-1 cis 1-bromo-4-tert-butylcyclohexyl acetic acid 
• 56300-88-0 (4-tert-Butyl-cyclohexylidene)-acetaldehyde 
• 56300-88-0 (aR)-(-)-(4-tert-butylcyclohexylidene)acetaldehyde 
• 41498-18-4 2-(4-tert-Butyl-cyclohexylidene)-ethanol 
• 85048-19-7 (aR)-(-)-(4-tert-butylcyclohexylidene)ethanol 
• 41498-18-4 2-(4-(tert-butyl)cyclohexylidene)ethanol 
• 123992-77-8 1-(diazoacetonylidene)-4-tert-butylcyclohexane 
• 56300-88-0 2-(4-tert-butylcyclohexylidene)acetaldehyde 

Relevant academic research and scientific papers

Chiral Alcoholates in Asymmetric Synthesis

Enantioselective dehydrohalogenation reactions with enantiomeric excesses (e.e.) as high as 90percent are promoted by chiral alcoholates as bases.

DERACEMIZATION OF AXIALLY DISSYMMETRIC COMPOUNDS BY ENANTIOSELECTIVE DEHYDROHALOGENATION USING CHIRAL LITHIUM AMIDES -II-

New findings about deracemization of unsaturated carboxylic acids 1 by enantioselective dehydrohalogenation of prochiral species 2 by chiral lithium amides leading to axially dissymmetric compounds with 80percent e.e. are reported.The role of the structure of the prochiral hydrochlorinated intermediate is discussed.An example of axial to central chirality transfer is described. (1a -> 3)

Deracemization by enantioselective dehydrohalogenation. Synthesis of optically active compounds bearing a chiral axis.

This work describes the deracemization of 4-tert-butyl and 4-methylcyclohexylidene acetic acids bearing a chiral axis.Enantioselective dehydrohalogenation of prochiral species by chiral lithium amides allowed us to obtain e.e. as high as 82percent.A mecha

A New, General Cyclopentenone Synthesis

A new synthesis of cyclopentenones, involving an Rh(II)-catalyzed, intramolecular carbon-hydrogen insertion of diazomethyl ketones derived from α,β-unsaturated acids, is described.

ENANTIOSELECTIVE DEHYDROHALOGENATION VIA ASYMMETRIC DEPROTONATION BY CHIRAL LITHIUM AMIDES: DERACEMIZATION OF A COMPOUND BEARING A CHIRAL AXIS

Chiral lithium amides exert asymmetric induction in dehydrohalogenation reactions leading to axially dissymmetric compounds.Thus the deracemization of 4-tert-butyl-cyclohexylidene acetic acid 1 via the prochiral hydrochlorinated intermediate 2 is reported

SYNTHESIS OF CYCLOHEXYLALIPHATIC ACIDS AND THEIR PHARMACOLOGICAL PROPERTIES

A series of substituted cyclohexylacetic acids I has been obtained by hydrogenation of the unsaturated analogues II and III.Esters of these analogues were prepared by the Horner-Wittig reaction of the corresponding cyclohexanones IV and/or 2-cyclohexenones V with triethyl phosphonoacetate.These esters were obtained in two isomeric forms (Z and E), differing in the double bond in the exo-position.The derivatives with a substituent in the 2-position exhibited a partial shift of the double bond to the cyclohexane ring; this shift was especially marked in the 2-phenyl derivative.With the acids I-III, activation of fibrinolysis was assessed by the hanging clot method; the anti-inflammatory effect was assessed by inhibition of two experimental model inflammations.The regression equation relating fibrinolytic capacity to lipophilicity was a quadratic one, the logarithm of optimum lipophilicity being log Popt = 5.55.A qualitative assessment of the anti-inflammatory effect in relation to lipophilicity suggests that log Popt is probably higher than with arylaliphatic acids.These acids seem to have an active site different from that of the acids I-III.