116496-66-3Relevant academic research and scientific papers
Rapid and highly efficient synthesis of thioureas in biocompatible basic choline hydroxide
Azizi, Najmedin,Farhadi, Elham
, p. 548 - 554 (2017)
A straightforward and convenient synthesis of symmetrical thiourea derivatives by the reaction of primary amines and carbon disulfide in biocompatible basic choline hydroxide is presented. A variety of biologically important thiourea derivatives can be obtained in good to excellent yields without a tedious work-up under mild reaction conditions. A series of primary aliphatic and aromatic amines with different substituted functional groups have been converted to thiourea derivatives under milder reaction conditions and short reaction times.
