116503-81-2Relevant academic research and scientific papers
Stereocontrolled synthesis of functionalised cyclohexanes via the lithium amide-mediated rearrangement of a meso 4,5-disubstituted cyclohexene oxide
O'Brien, Peter,Tournayre, Jerome J.
, p. 17527 - 17542 (2007/10/03)
Reaction of a 90:10 mixture of diastereomeric meso 4,5-disubstituted cyclohexene oxides (prepared via a stereoselective epoxidation reaction) with a mixed base system of a lithium amide and potassium tert-butoxide produces a 72% yield of an allylic alcohol and a 9.6% yield of recovered epoxide, both as single diastereoisomers. The relative stereochemistry of the epoxides and the allylic alcohol is established by converting the allylic alcohol into a novel bicyclic ether. The allylic alcohol is also used to prepare single diastereosiomers of a range of functionalised cyclohexanes.
Design, synthesis, and study of simple monocyclic conjugated enediynes. The 10-membered ring enediyne moiety of the enediyne anticancer antibiotics
Nicolaou,Zuccarello,Riemer,Estevez,Dai
, p. 7360 - 7371 (2007/10/02)
Following the discovery of the enediyne anticancer antibiotics, investigations were initiated directed toward the design, synthesis, and study of simple monocyclic conjugated enediynes. In this article the synthesis of the parent 10-membered ring enediyne
