116508-29-3Relevant academic research and scientific papers
Arylacetamides as peripherally restricted kappa opioid receptor agonists
Kumar, Virendra,Marella, Michael A.,Cortes-Burgos, Luz,Chang, An-Chih,Cassel, Joel A.,Daubert, Jeffrey D.,DeHaven, Robert N.,DeHaven-Hudkins, Diane L.,Gottshall, Susan L.,Mansson, Erik,Maycock, Alan L.
, p. 2567 - 2570 (2000)
Analogues of the kappa (κ) opioid receptor agonist, ICI 199441, were prepared. K(i) values for these analogues at the cloned human κ opioid receptor ranged from 0.058 to 25 nM. Trifluoromethylaryl derivatives were potent analgesics when administered subcu
Kappa agonist compounds and pharmaceutical formulations thereof
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, (2008/06/13)
Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compounds of formula IIIB have the structure: wherein R1, R2, R, Ar and n are as described in the specification.
Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
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, (2008/06/13)
Method for the prevention or treatment of pruritis by administering to a patient an antipruritic compound, or pharmaceutically acceptable salt thereof, of the class arylacetamide, which is exemplified by compounds of the formulae I, II, IIA, III, IV and IVA having the structures: and in which R1-4, X, X4, X5, X7, X9, Y and Z are as described in the specification.
Isothiocyanate-Substituted κ-Selective Opioid Receptor Ligands Derived from N-Methyl-N-phenylacetamide
Weerawarna, A. Ananda,Davis, Ronda D.,Nelson, Wendel L.
, p. 2856 - 2864 (2007/10/02)
The synthesis of isothiocyanate-substituted κ-selective opioid ligands derived from N-methyl-N-ethyl>phenylacetamide (8) and their effects in radioligand displacement assays are reported.Ligands 3-5 with the S-absolu
