Bioorganic and Medicinal Chemistry Letters p. 2567 - 2570 (2000)
Update date:2022-08-04
Topics:
Kumar, Virendra
Marella, Michael A.
Cortes-Burgos, Luz
Chang, An-Chih
Cassel, Joel A.
Daubert, Jeffrey D.
DeHaven, Robert N.
DeHaven-Hudkins, Diane L.
Gottshall, Susan L.
Mansson, Erik
Maycock, Alan L.
Analogues of the kappa (κ) opioid receptor agonist, ICI 199441, were prepared. K(i) values for these analogues at the cloned human κ opioid receptor ranged from 0.058 to 25 nM. Trifluoromethylaryl derivatives were potent analgesics when administered subcu
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