116538-96-6

Basic information

• Product Name: Thieno[3,2-b]pyridine-6-carbonitrile, 3-amino- (9CI)
• Synonyms: Thieno[3,2-b]pyridine-6-carbonitrile, 3-amino- (9CI);3-AMinothieno[3,2-b]pyridine-6-carbonitrile
• CAS NO: 116538-96-6
• Molecular Formula: C8H5N3S
• Molecular Weight: 175.2104
• Product Categories: THIENOPYRIDINE
• Mol File: 116538-96-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Thieno[3,2-b]pyridine-6-carbonitrile, 3-amino- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Thieno[3,2-b]pyridine-6-carbonitrile, 3-amino- (9CI)(116538-96-6)
• EPA Substance Registry System: Thieno[3,2-b]pyridine-6-carbonitrile, 3-amino- (9CI)(116538-96-6)

Safety Data

• Hazardous Substances Data: 116538-96-6(Hazardous Substances Data)

Usage

General Description

Thieno[3,2-b]pyridine-6-carbonitrile, 3-amino- (9CI) is a chemical compound with the molecular formula C8H5N3. It is a heterocyclic organic compound that contains a pyridine ring fused to a thieno ring and a carbonitrile group attached to the sixth position of the thieno ring. The compound is also known as 3-aminothieno[3,2-b]pyridine-6-carbonitrile and is used in the synthesis of pharmaceuticals and agrochemicals due to its potential biological activities. Thieno[3,2-b]pyridine-6-carbonitrile, 3-amino- (9CI) may also have applications in material science and organic electronics due to its unique structural properties. However, further research is needed to fully explore the potential uses and properties of this chemical compound.

Upstream product

• 78637-85-1 thiophene-3,4-diamine 
• 105161-33-9 sodium (E)-2-cyano-3,3-dimethoxy-prop-1-en-1-olate 
• 90069-81-1 thiophene-3,4-diamine dihydrochloride 

Downstream Products

• 1600508-25-5 (R)-3-((3-(5-(chloroamino)-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-amino)thieno[3,2-b]pyridine-6-carbonitrile 
• 1600508-26-6 (R)-3-((3-(5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-amino)-2-chlorothieno[3,2-b]pyridine-6-carbonitrile 
• 1600507-18-3 3-((3-((3R)-5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)amino)thieno[3,2-b]pyridine-6-carbonitrile 

Relevant articles and documents

PREPARATION AND APPLICATION OF AROMATIC COMPOUND HAVING IMMUNOREGULATORY FUNCTION

Provided are an aromatic compound having immunoregulatory effect, a preparation method thereof, and a use of the same in regulating immune responses or inhibiting PD-1/PD-L1.

AMINO-DIHYDROTHIAZINE AND AMINO-DIOXIDO DIHYDROTHIAZINE COMPOUNDS AS BETA-SECRETASE ANTAGONISTS AND METHODS OF USE

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A8, R1, R2, R3, R7 and n of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formula II and sub-formula embodiments thereof, intermediates and processes and methods useful for the preparation of compounds of Formulas I-II.

Facile Synthesis of Annelated NADH Model Precursors

A convenient route to γ-cyano fused pyridine derivatives, which are precursors of NADH models, is described.The method involves the reaction of 3,3-dimethoxy-2-formyl-propionitrile sodium salt (1) with amino derivatives of electron donating heterocyles le