78637-85-1

Basic information

• Product Name: 3,4-Diaminothiophene dihydrobromide
• Synonyms: 3,4-Diaminothiophene2HCl;3,4-Diaminothiophene dihydrobromide;3,4-Thiophenediamine dihydrobromide;3,4-DIAMINOTHIOPHENE;thiophene-3,4-diaMinedihydrochloride;thiophene-3,4-diamine HCl;3,4-DIAMINOTHIOPHENE(WXG03192)
• CAS NO: 78637-85-1
• Molecular Formula: C₄H₆N₂S
• Molecular Weight: 275.99
• Product Categories: Metal Isotopes;Sulfur & Selenium Compounds
• Mol File: 78637-85-1.mol
• Article Data: 16

Chemical Properties

• Melting Point: 150 °C
• Boiling Point: 385.5°C at 760 mmHg
• Flash Point: 186.9°C
• Appearance: /
• Density: 1.367±0.06 g/cm3(Predicted)
• Vapor Pressure: 2.55E-06mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 4.13±0.10(Predicted)
• CAS DataBase Reference: 3,4-Diaminothiophene dihydrobromide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Diaminothiophene dihydrobromide(78637-85-1)
• EPA Substance Registry System: 3,4-Diaminothiophene dihydrobromide(78637-85-1)

Safety Data

• Hazard Codes: Xn
• Statements: 39-20/21/22
• Safety Statements: 24/25
• Hazardous Substances Data: 78637-85-1(Hazardous Substances Data)

Usage

Chemical Properties

Light Brown Solid

InChI:InChI=1/C4H6N2S.2ClH/c5-3-1-7-2-4(3)6;;/h1-2H,5-6H2;2*1H

Upstream product

• 52431-30-8 2,5-dibromo-3,4-dinitrothiophene 
• 3141-26-2 3,4-dibromothiophene 
• 90069-81-1 thiophene-3,4-diamine dihydrochloride 

Downstream Products

• 632334-68-0 2-chloromethyl-1H-thieno[3,4-d]imidazole 
• 116538-96-6 3-aminothieno[3,2-b]pyridine-6-carbonitrile 
• 1381779-55-0 2-(4-(methylsulfonyl)phenyl)thieno[3,4-b]pyrazine 
• 1130864-42-4 3,4-dibromoacenaphtho[1,2-b]thieno[3,4-e]pyrazine 

Relevant articles and documents

Synthesis and characterization of new 2,3-disubstituted thieno[3,4-b]pyrazines: Tunable building blocks for low band gap conjugated materials

(Chemical Equation Presented) Synthetic methods have been developed for the preparation of new 2,3-dihalothieno[3,4-b]pyrazines, from which a variety of new 2,3-difunctionalized thieno[3,4-b]pyrazines have been produced as precursors to conjugated materials. Structural, electronic, and optical characterization of these new analogues illustrate the extent to which the electronic nature of the functional groups can be used to tune the electronic properties of the thieno[3,4-b]pyrazine unit.

Discovery of novel 4-aryl-thieno[1,4]diazepin-2-one derivatives targeting multiple protein kinases as anticancer agents

A series of 4-aryl-thieno[1,4]diazepin-2-one were synthesized and evaluated for their antiproliferative activities against the A375P melanoma and U937 hematopoietic cell lines. Several compounds showed very potent antiproliferative activities toward both cell lines and the activities were better than that of sorafenib, the reference standard. Derivatives were made as amide (8a–8i, 9a–9m) and urea (10a–10d, 11a–11d) with diverse hydrophobic moieties. One of the most potent inhibitor 10d, 1-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(4-(2-oxo-2,3-dihydro-1H-thieno [3,4-b][1,4]diazepin-4-yl)phenyl)urea was found to be very potent inhibitor of multi-protein kinases including FMS kinase (IC50 = 3.73 nM) and is a promising candidate for further development in therapeutics for cancer.

INHIBITORS TARGETING DRUG-RESISTANT INFLUENZA A

Provided are compounds according to formula (la) or (lb) as described herein, that are capable of modulating the activity of influenza viruses (e.g., influenza A virus), for example, via interaction with the M2 transmembrane protein, and other similar viroporins. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds according to according to formulas (la') or (lb), as described herein.