116539-58-3

Basic information

• Product Name: duloxetine
• Synonyms: (r)-n-methyl-gama-(1-naphthalenyloxy)-2-thiophenepropanamine; R-DULOXETINE HCL; (R)-Duloxetine; (3R)-N-methyl-3-(naphthalen-1-yloxy)-3-thiophen-2-ylpropan-1-amine; ; (3S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine; 2-Thiophenepropanamine, N-methyl-gamma-(1-naphthalenyloxy)-; 2-thiophenepropanamine, N-methyl-gamma-(1-naphthalenyloxy)-, (gammaR)-; N-Methyl-gamma-(1-naphthalenyloxy)-2-thiophenepropanamine; N-methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine
• CAS NO: 116539-58-3
• Molecular Formula: C₁₈H₁₉NOS
• Molecular Weight: 297.41456
• Mol File: 116539-58-3.mol
• Article Data: 62

Chemical Properties

• Boiling Point: 466.2°C at 760 mmHg
• Flash Point: 235.7°C
• Appearance: /
• Density: 1.158g/cm³
• Vapor Pressure: 7.23E-09mmHg at 25°C
• Refractive Index: 1.627
• CAS DataBase Reference: duloxetine(CAS DataBase Reference)
• NIST Chemistry Reference: duloxetine(116539-58-3)
• EPA Substance Registry System: duloxetine(116539-58-3)

Safety Data

• Hazardous Substances Data: 116539-58-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m1/s1

Upstream product

• 321-38-0 1-Fluoronaphthalene 
• 116539-55-0 (S)-3-methylamino-1-(2-thienyl)-1-propanol 
• 7631-86-9 SiO₂ 
• 136434-34-9 duloxetine hydrochloride 
• 14756-03-7 3-(2-thienyl)acrolein 
• 90-15-3 α-naphthol 
• 74-89-5 methylamine 
• 953028-77-8 1-chloroethyl-N-methyl-((S)-3-(naphthalene-1-yloxy)-3-(thiophen-2-yl)propyl)carbamate 
• 116817-13-1 duloxetine 
• 13636-02-7 3-(N,N-dimethylamino)-1-(thien-2-yl)propan-1-ol 
• 89639-64-5 (E)-3-(thien-2-yl)prop-2-en-1-ol 
• 1124-65-8 3-(2-thienyl)-2-propenoic acid 
• 1620141-95-8 C₂₀H₁₇NS 
• 39511-07-4 (E)-2-(2-thienyl)ethylene-1-carbaldehyde 

Downstream Products

• 116817-86-8 (+)-(S)-N-methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine maleate 
• 136434-34-9 duloxetine hydrochloride 
• 116817-13-1 duloxetine 
• 1033719-36-6 2-(1-(2-hydroxynaphth-1-yl)-3-(methylamino)propyl)-thiophene hydrochloride 
• 953028-76-7 2-(1-(4-hydroxynaphth-1-yl)-3-(methylamino)propyl)-thiophene hydrochloride 
• 90-15-3 α-naphthol 
• 132335-46-7 N-methyl-(S)-duloxetine 
• 1309349-73-2 ketorolac (S)-duloxetine salt 
• 1309349-74-3 nimesulide (S)-duloxetine salt 
• 1309349-83-4 diclofenac (S)-duloxetine salt 
• 1309349-71-0 acemetacin (S)-duloxetine salt 
• 1309349-90-3 sulindac (S)-duloxetine salt 
• 949096-01-9 (+/-)-N-methyl-3-(2-thienyl)-3-(4-hydroxy-naphtyl)-propylamine hydrogenbromide 

Related news

Preclinical evidence of enhanced analgesic activity of duloxetine (cas 116539-58-3) complexed with succinyl-β-cyclodextrin: A comparative study with cyclodextrin complexes08/16/2019

Chronic pain represents one of the most important public health problems, with a great prevalence of comorbidity with depression and cognitive decline. Antidepressants such as duloxetine, a serotonin-norepinephrine reuptake inhibitor, represent an essential part of the therapeutic strategy for c...detailed

duloxetine (cas 116539-58-3) plasma level and antidepressant response08/15/2019

BackgroundMajor Depressive Disorder (MDD) is associated with a high rate of inadequate treatment response, which is mainly due to the large inter-individual genetic variability in pharmacokinetic and pharmacodynamic targets of antidepressant drugs. Little is still known about the exact associati...detailed

Stability and toxicity studies for duloxetine (cas 116539-58-3) and econazole on Spirodela polyrhiza using chiral capillary electrophoresis08/14/2019

Stability and toxicity studies for duloxetine and econazole were achieved using individual solutions and their mixtures. Stability of drugs racemates and enantiomers was investigated under abiotic and biotic conditions. Toxicity was evaluated for the first time on Spirodela polyrhiza. EC50 value...detailed

Relevant articles and documents

An Improved Process for Synthesis of (S)-Duloxetine Hydrochloride Involving Enzymatic Asymmetric Carbonyl Reduction on a Novel Ketoamine

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Duloxetine hydrochloride salt of basic and duloxetine (by machine translation)

[Problem] to suppress toxic byproducts, and suppressing the formation of decomposition products of high purity optical isomers as well as the method for manufacturing a basic duloxetine hydrochloride duloxetine. [Solution] a basic manufacturing method of duloxetine, [...], potassium hydroxide and toluene in the presence of alcohol in the mixing step, and, by heating the reaction mixture obtained, comprising the step of distilling off the solvent in the reaction portion, a basic manufacturing method of duloxetine. [Drawing] no (by machine translation)

Chemoenzymatic synthesis of (S)-duloxetine using carbonyl reductase from Rhodosporidium toruloides

A chemoenzymatic strategy was developed for (S)-duloxetine production employing carbonyl reductases from newly isolated Rhodosporidium toruloides into the enantiodetermining step. Amongst the ten most permissive enzymes identified, cloned, and overexpressed in Escherichia coli, RtSCR9 exhibited excellent activity and enantioselectivity. Using co-expressed E. coli harboring both RtSCR9 and glucose dehydrogenase, (S)-3-(dimethylamino)-1-(2-thienyl)-1-propanol 3a was fabricated with so far the highest substrate loading (1000 mM) in a space-time yield per gram of biomass (DCW) of 22.9 mmol L-1 h-1 g DCW-1 at a 200-g scale. The subsequent synthetic steps from RtSCR9-catalyzed (S)-3a were further performed, affording (S)-duloxetine with 60.2% overall yield from 2-acethylthiophene in >98.5% ee.