116541-34-5Relevant academic research and scientific papers
Synthesis and platelet aggregation inhibitory effects of harman and phthalide derivatives related to ligusticum chuanxiong (Hort.) constituents
Foye, William O.,Wang, Xiping,Hongfu, Wang
, p. 180 - 191 (2007/10/03)
The Chinese drug plant Ligusticum chuanxiong (Hort.) has platelet aggregation inhibiting effects, and also protects against sub-lethal radiation doses that cause capillary hypercoagulation. Two types of derivatives of known constituents of this plant have been synthesized and tested for inhibition of hypercoagulation. These include harman and phthalide derivatives. The harman derivatives showed good inhibitory effects against platelet aggregation in rabbit heart blood ranging from 39-96%. The phthalides gave 0-19% inhibitions.
