1165713-32-5Relevant academic research and scientific papers
Factors affecting orthogonality in the deprotection of 2,4-di-protected aromatic ethers employing solid-supported acids
Tangdenpaisal, Kassrin,Sualek, Supannee,Ruchirawat, Somsak,Ploypradith, Poonsakdi
experimental part, p. 4316 - 4325 (2009/10/17)
Selective deprotection of aromatic ethers bearing two protecting groups on the same aromatic ring by solid-supported acids (Amberlyst-15 and PTS-Si) was systematically investigated. ortho-Directing protonation by the carbonyl group as well as carbocation stability and quenching are the important determining factors for the orthogonal deprotection process. Stablilized carbocations (e.g., those from the MOM and PMB groups) could be removed with high selectivity.
