116592-71-3

Upstream product

• 100-44-7 benzyl chloride 
• 123-08-0 4-hydroxy-benzaldehyde 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 105-56-6 ethyl 2-cyanoacetate 

Relevant academic research and scientific papers

Kinetic insights of DNA/RNA segment salts catalyzed knoevenagel condensation reaction

In this work, we demonstrated that (i) salts of RNA/DNA segments were capable of catalyzing Knoevenagel condensation at physiological pH 7.0 with efficiency comparable to one of the best enzymes, porcine pancreatic lipase (PPL); and (ii) a broad scope of

Solid-supported continuous flow synthesis in microreactors using electroosmotic flow

This paper reports the fabrication of a microreactor suitable for use with supported reagents. We demonstrate that the electroosmotic flow can be used to move the reagents over a solid-supported catalyst bed. It is demonstrated that it is important that the support should not swell in organic solvents to obtain reproducible flow, and it is shown that silica supports fulfill this criteria. Silica-functionalised piperazine is used in a variety of Knoevenagel reactions to give the product in high conversion.

The preparation and reaction of enolates within micro reactors

Over the past 5 years, interest in the miniaturisation of chemical synthesis has grown rapidly, however in order to facilitate transfer of the technology from its current position as a research tool to industrial applications, a core understanding of the challenges associated with transferring reactions from the macro to the micro domain is required. This paper therefore aims to broach this problem by investigating the application of micro reactors to a range of commonly employed synthetic reactions including acylation, aldol, alkylation, 1,4-conjugate addition (Michael addition) and the Knoevenagel condensation. Comparison of the results obtained with traditional batch techniques enable us to highlight some of the advantages associated with micro reaction technology.

Synthetic process of 3-(4-benzyloxy-phenyl)-2-cyanoacrylate

The invention discloses a synthetic process of 3-(4-benzyloxy-phenyl)-2-cyanoacrylate. The synthetic process includes the following steps of 1, under an inert atmosphere, blending and stirring p-hydroxy benzaldehyde, benzyl halide, alkali, a solvent and a catalyst at the room temperature for 3-10 hours, then pouring the mixture into water, using an extraction agent for extraction, and sequentiallyconducting washing, drying and concentration on an organic phase to obtain an intermediate 4-(phenyl-methoxy) benzaldehyde; 2, under the inert atmosphere, making 4-(phenyl-methoxy) benzaldehyde, acetic acid, ethyl cyanoacetate and a catalytic amount of piperidine subjected to a reflux reaction in methylbenzene for 3-12 hours; after the reaction is finished, lowering the temperature to the room temperature, adding a quenching agent, and sequentially conducting washing, drying, concentration and purification on the organic phase to obtain 3-(4-benzyloxy-phenyl)-2-cyanoacrylate. The synthetic process is low in preparation cost, high in yield and simple in aftertreatment.

Synthesis and schistosomicidal activity of new substituted thioxo-imidazolidine compounds

Synthesis and physico-chemical properties of 3-benzyl-5-(4-fluoro- benzylidene)-1-methyl-2-thioxo-imidazolidin-4-ones, 5-benzylidene-3-(4-nitro- benzyl)-2-thioxo-imidazolidin-4-onesand4-acridin-9-ylmethylene-1-benzyl-5- thioxo-imidazolidin-2-ones compounds are described. These thioxo-imidazolidine derivatives were prepared by alkylation and condensation with 4-fluoro-benzaldehyde or nucleophilic Michael addition with cyanoacrylates. The schistosomicidal activity of 3-benzyl-5-(4-fluoro-benzylidene)-1-methyl-2- thioxo-imidazolidin-4-one compounds was evaluated.

A novel way of synthesis of 1,3,5-trisubstituted-2-thioxoimidazolidinones

Title compounds were prepared by 1,4-nucleophilic addition of 2-thioxoimidazolidin-4-ones to 3-aryl-2-cyano acrylates, followed by alkylation. Reaction yield are much better than those obtained in case of Knoevenagel-type condensation.