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CAS

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116604-04-7

Imidodicarbonimidic diamide, N-(4-hydroxyphenyl)-, monohydrochloride is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 116604-04-7 Structure

  • Basic information

    1. Product Name: Imidodicarbonimidic diamide, N-(4-hydroxyphenyl)-, monohydrochloride
    2. Synonyms:
    3. CAS NO:116604-04-7
    4. Molecular Formula: C8H11N5O.ClH
    5. Molecular Weight: 229.669
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 116604-04-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Imidodicarbonimidic diamide, N-(4-hydroxyphenyl)-, monohydrochloride(CAS DataBase Reference)
    10. NIST Chemistry Reference: Imidodicarbonimidic diamide, N-(4-hydroxyphenyl)-, monohydrochloride(116604-04-7)
    11. EPA Substance Registry System: Imidodicarbonimidic diamide, N-(4-hydroxyphenyl)-, monohydrochloride(116604-04-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 116604-04-7(Hazardous Substances Data)

116604-04-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 116604-04-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,6,6,0 and 4 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 116604-04:
(8*1)+(7*1)+(6*6)+(5*6)+(4*0)+(3*4)+(2*0)+(1*4)=97
97 % 10 = 7
So 116604-04-7 is a valid CAS Registry Number.

116604-04-7Relevant articles and documents

Discovery of Small-Molecule Cyclic GMP-AMP Synthase Inhibitors

Anderson, Rachel,Chen, Zhijian J.,Padilla-Salinas, Rosaura,Sun, Lijun,Yang, Xikang,Yin, Hang,Zhang, Shuting

, (2020/02/04)

Cyclic guanosine monophosphate-adenosine monophosphate (GMP-AMP) (cGAS), a cytosolic DNA sensor, plays an important role in the type I interferon response. DNA from either invading microbes or self-origin triggers the enzymatic activity of cGAS. Aberrant activation of cGAS is associated with various autoimmune disorders. Only one selective probe exists for inhibiting cGAS in cells, while others are limited by their poor cellular activity or specificity, which underscores the urgency for discovering new cGAS inhibitors. Here, we describe the development of new small-molecule human cGAS (hcGAS) inhibitors (80 compounds synthesized) with high binding affinity in vitro and cellular activity. Our studies show CU-32 and CU-76 selectively inhibit the DNA pathway in human cells but have no effect on the RIG-I-MAVS or Toll-like receptor pathways. CU-32 and CU-76 represent a new class of hcGAS inhibitors with activity in cells and provide a new chemical scaffold for designing probes to study cGAS function and development of autoimmune therapeutics.

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