116611-37-1Relevant articles and documents
Asymmetric transfer hydrogenation of heterocycle-containing acetophenone derivatives using N-functionalised [(benzene)Ru(II)(TsDPEN)] complexes
Barrios-Rivera, Jonathan,Xu, Yingjian,Clarkson, Guy J.,Wills, Martin
supporting information, (2021/12/02)
The application of enantiomerically-pure ruthenium(II) catalysts containing N - functionalised TsDPEN ligand to the asymmetric transfer hydrogenation of 15 examples of α-heterocyclic acetophenone derivatives is reported. Products of up to 99% ee were formed.
Palladium-Catalyzed Enantioselective Decarboxylative Allylic Alkylation of Acyclic α- N-Pyrrolyl/Indolyl Ketones
Alexy, Eric J.,Lavernhe, Remi,Stoltz, Brian M.,Zhang, Haiming
supporting information, (2020/06/05)
The synthesis of fully substituted α-N-pyrrolyl and indolyl ketones via enantioselective palladium-catalyzed allylic alkylation is described. The acyclic ketones are alkylated in high yields with high enantioselectivities through the use of an electron-deficient phosphinooxazoline ligand, furnishing a highly congested and synthetically challenging stereocenter. The obtained alkylation products contain multiple reactive sites poised for additional functionalizations and diversification.
Synthesis of (Z)-N-alkenylazoles and pyrroloisoquinolines from α-N-azoleketones through Pd-catalyzed tosylhydrazone cross-couplings
Florentino, Lucia,Aznar, Fernando,Valdes, Carlos
supporting information, p. 10506 - 10510 (2013/08/23)
Azoles reacting in tandem: The ortho-stereodirecting effect is the key to the stereoselective synthesis of (Z)-N-alkenylazoles I through the tosylhydrazide-mediated Pd-catalyzed cross-coupling reaction of α-N-azoleacetophenones with ortho-substituted aryl halides and nonaflates (see scheme). Additionally, the preorganization of the alkene allowed for the development of an auto-tandem reaction involving an intramolecular C-H arylation leading to pyrroloisoquinolines II. Copyright
