116611-44-0

Basic information

• Product Name: ((R)-2-benzenesulfonyl-1-hydroxymethyl-ethyl)carbamic acid tert-butyl ester
• Synonyms: ((R)-2-benzenesulfonyl-1-hydroxymethyl-ethyl)carbamic acid tert-butyl ester
• CAS NO: 116611-44-0
• Molecular Weight: 315.39
• Mol File: 116611-44-0.mol

Chemical Properties

• CAS DataBase Reference: ((R)-2-benzenesulfonyl-1-hydroxymethyl-ethyl)carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: ((R)-2-benzenesulfonyl-1-hydroxymethyl-ethyl)carbamic acid tert-butyl ester(116611-44-0)
• EPA Substance Registry System: ((R)-2-benzenesulfonyl-1-hydroxymethyl-ethyl)carbamic acid tert-butyl ester(116611-44-0)

Safety Data

• Hazardous Substances Data: 116611-44-0(Hazardous Substances Data)

Upstream product

• 116611-43-9 (R)-2-tert-butyl carbamoyl-1-hydroxy-3-(phenylthio)propane 
• 2766-43-0 N-tert-butyloxycarbonyl-L-serine methyl ester 
• 56926-94-4 methyl (2S)-2-[N-(t-butoxycarbonyl)amino]-3-(4-methylbenzenesulfonyl)-oxypropionate 
• 1043499-68-8 (R)-S-benzenesulfonyl-2-tert-butoxycarbonylamino-propionic acid methyl ester 
• 116611-42-8 (R)-2-tert-butoxycarbonylamino-3-phenylsulfanylpropionic acid methyl ester 

Downstream Products

• 1043494-36-5 (R)-4-benzenesulfonylmethyl-4,5-dihydrooxazol-2-ylamine 
• 116611-51-9 [(R)-2-Benzenesulfonyl-3-phenyl-1-(tetrahydro-pyran-2-yloxymethyl)-propyl]-carbamic acid tert-butyl ester 
• 116611-53-1 [(R)-2-Benzenesulfonyl-1-(tetrahydro-pyran-2-yloxymethyl)-pentyl]-carbamic acid tert-butyl ester 
• 116611-52-0 [(R)-2-Benzenesulfonyl-1-(tetrahydro-pyran-2-yloxymethyl)-butyl]-carbamic acid tert-butyl ester 
• 116611-60-0 ((R)-2-Benzenesulfonyl-1-hydroxymethyl-3-phenyl-propyl)-carbamic acid tert-butyl ester 
• 116611-62-2 ((R)-2-Benzenesulfonyl-1-hydroxymethyl-pentyl)-carbamic acid tert-butyl ester 
• 116611-61-1 ((R)-2-Benzenesulfonyl-1-hydroxymethyl-butyl)-carbamic acid tert-butyl ester 
• 116611-54-2 (1S-hydroxymethyl-3-phenylpropyl)carbamic acid tert-butyl ester 
• 116611-57-5 tert-butyl [(1S)-1-(hydroxymethyl)butyl]carbamate 
• 116640-17-6 tert-butyl [(1S)-1-(hydroxymethyl)pentyl]carbamate 
• 82732-07-8 Boc-L-homophenylalanine 
• 6404-28-0 Boc-Nle-OH 
• 53308-95-5 N-tert-butoxycarbonyl-L-norvaline 
• 253776-40-8 (2R,5S)-3-Benzenesulfonyl-2,5-bis-benzyloxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

NOVEL 2-AMINOOXAZOLINES AS TAAR1 LIGANDS FOR CNS DISORDERS

The invention relates to the use of compounds of Formula (I) wherein R 1 is hydrogen, deuterium, tritium, lower alkyl, lower alkoxy, lower alkyl substituted by halogen, lower alkoxy substituted by halogen, halogen, phenyl optionally substituted by halogen, or is phenyloxy, benzyl, benzyloxy, -COO-lower alkyl, -O-(CH 2 ) o -O-lower alkyl, NH-cycloalkyl, cycloalkyl or tetrahydropyran-4-yloxy, wherein the substituents for n> 1 may be the same or different; X is a bond, -CHR-, -CHRCHR'-, -OCH 2 -, -CH 2 OCHR-, -CH 2 CH 2 CH 2 -, -SCH 2 -, -S(O) 2 CH 2 -, -CH 2 SCH 2 -, -CH 2 N(R)CH 2 -, -cycloalkyl-CH 2 - or SiRR'-CH 2 -; R/R' may be independently from each other hydrogen, lower alkyl or lower alkyl substituted by halogen; R 2 is hydrogen, phenyl or lower alkyl; Y is phenyl, naphthyl, thiophenyl, pyridinyl, cycloalkyl, 1,2,3,4-tetrahydro-naphthalen-2-yl, 2,3-dihydrobenzo[1,4]dioxin-6-yl or benzo[1,3]dioxol-5-yl; n is 0, 1, 2 or 3; o is 2 or 3; or to a pharmaceutically suitable acid addition salt for the manufacture of medicaments for the treatment of diseases related to the biological function of the trace amine associated receptors, which diseases are depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders, schizophrenia, neurological diseases, Parkinson's disease, neurodegenerative disorders, Alzheimer's disease, epilepsy, migraine, substance abuse and metabolic disorders, eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders

A NOVEL APPROACH TO THE SYNTHESIS OF OPTICALLY PURE NON PROTEIN α-AMINO ACIDS IN BOTH L AND D CONFIGURATIONS FROM L-SERINE

Efficient syntheses of (2R)-2-Boc-amino-3-phenylsulfonyl-1-propanol 3 and its enantiomer 9 from L-serine are described.The potential of these compounds in a novel general method for the synthesis of optically pure non protein α-amino acids in both the L and D configurations is exemplified by the preparation of N-Boc-L-and D-homophenylalanine,-norvaline and -norleucine.