3393-64-4

Basic information

• Product Name: 4-HYDROXY-3-METHYL-2-BUTANONE
• Synonyms: 4-HYDROXY-3-METHYL-2-BUTANONE;3-(Hydroxymethyl)-2-butanone;4-hydroxy-3-methylbutan-2-one;4-HYDROXY-4-METHYL-2-BUTANONE;1-Hydroxy-2-methyl-3-butanone;4-Hydroxy-3-methyl-2-butanone,85%,tech.;4-Hydroxy-3-methyl-2-butanone, tech 85%;4-hydroxy-3-methylbutan-2-one(WXC09112)
• CAS NO: 3393-64-4
• Molecular Formula: C₅H₁₀O₂
• Molecular Weight: 102.13
• EINECS: 222-238-6
• Mol File: 3393-64-4.mol
• Article Data: 9

Chemical Properties

• Melting Point: 2.5°C (estimate)
• Boiling Point: 90-95 °C/15 mmHg(lit.)
• Flash Point: 79 °C
• Appearance: /
• Density: 0.993 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.153mmHg at 25°C
• Refractive Index: n20/D 1.438(lit.)
• PKA: 14.44±0.10(Predicted)
• Sensitive: Hygroscopic
• CAS DataBase Reference: 4-HYDROXY-3-METHYL-2-BUTANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-3-METHYL-2-BUTANONE(3393-64-4)
• EPA Substance Registry System: 4-HYDROXY-3-METHYL-2-BUTANONE(3393-64-4)

Safety Data

• Safety Statements: S24/25:Avoid contact with skin and eyes.
• Hazardous Substances Data: 3393-64-4(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

Protonated diacetone alcohol and protonated 4- hydroxy-3-methyl-2-butanone undergo ?vinylation? and colli- sion-induced dehydration as the only primary reactions, the product of the former reaction consisting of up to 40% of the total product ion distribution.

InChI:InChI=1/C5H10O2/c1-4(3-6)5(2)7/h4,6H,3H2,1-2H3/t4-/m1/s1

Upstream product

• 814-78-8 3-Methyl-3-buten-2-one 
• 50-00-0 formaldehyd 
• 78-93-3 butanone 
• 6868-97-9 3-oxo-2,2-bis-(hydroxymethyl)butane 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 13523-18-7 4-hydroxy-3-methyl-3-phenylsulfanyl-butan-2-one 
• 7732-18-5 water 
• 78-94-4 methyl vinyl ketone 
• 73255-29-5 3-(hydroxymethyl)but-3-en-2-one 
• 98051-59-3 2-methyl-2-(2-hydroxy-1-methylethyl)-1,3-dithiane 
• 4587-00-2 2-acetyl-2-methyloxirane 
• 27773-09-7 carbethoxy-1 ethylene dioxy-2 methyl-1 propane 
• 609-14-3 2-acetylpropanoic acid ethyl ester 
• 89358-46-3 4-hydroxy-3-methylbutan-2-one ethylene acetal 

Downstream Products

• 1660-93-1 3,4,7,8-Tetramethyl-o-phenanthrolin 
• 1531-20-0 3,4-dimethyl-8-nitro-quinoline 
• 72681-39-1 3,4,7-trimethyl-quinoline 
• 91181-50-9 4-<4-Nitro-anilino>-3-methyl-butanon-(2) 
• 91332-86-4 4-(2,4-Dinitro-anilino)-3-methyl-butanon-⁽²⁾ 
• 90047-25-9 Toluene-4-sulfonic acid 2-methyl-3-oxo-butyl ester 
• 14366-96-2 (2R*,3R*)-2-methyl-3-phenyl-1,3-butanediol 
• 193958-68-8 3,4-dihydroxy-3-methyl-2-butanone 
• 193958-68-8 3,4-dihydroxy-3-methyl-2-butanone 
• 116614-13-2 (2R*,3R*)-2,3,4-trimethyl-1,3-pentanediol 
• 116614-13-2 (2R*,3S*)-2,3,4-trimethyl-1,3-pentanediol 
• 14366-97-3 (2R*,3S*)-2-methyl-3-phenyl-1,3-butanediol 
• 814-78-8 3-Methyl-3-buten-2-one 
• 6110-10-7 (+/-)-3-Methyl-4-phenylsulfanylbutan-2-one 

Relevant articles and documents

Chelation, activation, and proximity effects in the deprotection of dithianes with ZnBr2. Applications in the polyketide field

(Matrix presented) Double deprotection of dithiane aldol equivalents is feasible under mild conditions with ZnBr2 and suitably placed MEM, BOM, and SEM groups which function as protecting, activating, and regiodirecting groups. The procedure is useful in natural product synthesis.

Method for preparing 3, 4-dimethylpyrazole and phosphate thereof

The invention discloses a method for preparing 3, 4-dimethylpyrazole and phosphate thereof. The method for preparing the 3, 4-dimethylpyrazole includes the steps: (1) feeding 2-butanone, aldehyde andalkali solution into a microchannel reactor and performing aldehyde ketone condensation reaction to produce 4-hydroxy-3-methyl-2-butanone salt; (2) mixing reaction liquid obtained in the step (1) andacid liquid in the microchannel reactor to obtain 4-hydroxy-3-methyl-2-butanone water solution; (3) performing reaction on hydrazine hydrate and the 4-hydroxy-3-methyl-2-butanone water solution in themicrochannel reactor, mixing reaction liquid with the alkali solution and hydrogen peroxide, and performing oxidative dehydrogenation reaction to obtain 3, 4-dimethylpyrazole water solution; (4) performing organic extraction and distillation on the 3, 4-dimethylpyrazole water solution to obtain the 3, 4-dimethylpyrazole. According to the method, reaction time is greatly shortened, the yield and the purity of products are ensured, and continuous production can be realized.

COMPOUND AND METHOD FOR THE TREATMENT OF PAIN

The disclosure herein provides a compound of formula 1. The disclosure also provides a method of synthesizing the compound of formula 1. The compound of formula 1 or its pharmaceutical acceptable salts, as well as polymorphs, solvates, and hydrates thereof may be formulated as pharmaceutical composition. The pharmaceutical composition of compound of formula 1 or the final compound may be formulated for non-invasive peroral, topical (example transdermal), enteral, transmucosal, targeted delivery, sustained release delivery, delayed release, pulsed release and parenteral methods. Such compositions may be used to treat chronic pain manifested with chronic diseases or its associated complications.