1166391-13-4

Basic information

• Product Name: (E)-4-(3,4-bis(methoxymethoxy)phenyl)but-3-en-2-one
• Synonyms: (E)-4-(3,4-bis(methoxymethoxy)phenyl)but-3-en-2-one
• CAS NO: 1166391-13-4
• Molecular Weight: 266.294
• Mol File: 1166391-13-4.mol

Chemical Properties

• CAS DataBase Reference: (E)-4-(3,4-bis(methoxymethoxy)phenyl)but-3-en-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-4-(3,4-bis(methoxymethoxy)phenyl)but-3-en-2-one(1166391-13-4)
• EPA Substance Registry System: (E)-4-(3,4-bis(methoxymethoxy)phenyl)but-3-en-2-one(1166391-13-4)

Safety Data

• Hazardous Substances Data: 1166391-13-4(Hazardous Substances Data)

Upstream product

• 6515-06-6 3,4-bis-methoxymethoxy-benzaldehyde 
• 67-64-1 acetone 

Downstream Products

• 404338-74-5 4-(3,4-bis(methoxymethoxy)phenyl)butan-2-one 
• 123694-03-1 (E)-4-(3′,4′-dihydroxyphenyl)but-3-en-2-one 

Relevant articles and documents

Methyl caffeate as an α-glucosidase inhibitor from solanum torvum fruits and the activity of related compounds

In screening experiments for rat intestinal α-glucosidase (sucrase and maltase) inhibitors in 325 plants cultivated in Japan's southern island, of Tanegashima, marked inhibition against both sucrase and maltase was found in the extract of the fruit of Solanum torvum. Enzyme-assay guided fractionation of the extract led to the isolation of methyl caffeate (1) as a rat intestinal sucrase and maltase inhibitor. We examined 13 caffeoyl derivatives for sucrase- and maltase-inhibitory activities. The results showed that methyl caffeate (1) had a most favorable structure for both sucrase and maltase inhibition, except for a higher activity of methyl 3,4,5-trihydroxycinnamate (14) against sucrase. Its moderate inhibitory action against α-glucosidase provides a prospect for antidiabetic usage of S. torvum fruit.

Synthesis of two alnustone-like natural diarylheptanoids via 4+3 strategy

The first total synthesis of (4E,6E)-1,7-bis(3,4-dihydroxyphenyl)-hepta-4, 6-dien-3-one and an alternative synthesis of (4E,6E)-1,7-bis(4-hydroxyphenyl)- hepta-4,6-dien-3-one, two natural diarylheptanoids, mainly based on Claisen-Schmidt condensation were described. The crucial steps of the syntheses were the condensation of OH-protected 4-aryl-2-butanones with OH-protected 3-aryl-acrylaldehydes by the in situ enamination and then deprotection of OH groups to give the corresponding natural diarylheptanoids. Copyright Taylor & Francis Group, LLC.