1166394-11-1

Basic information

• Product Name: C₄₄H₅₆N₇O₇P
• CAS NO: 1166394-11-1
• Molecular Weight: 825.945
• Mol File: 1166394-11-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₄H₅₆N₇O₇P(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₄H₅₆N₇O₇P(1166394-11-1)
• EPA Substance Registry System: C₄₄H₅₆N₇O₇P(1166394-11-1)

Safety Data

• Hazardous Substances Data: 1166394-11-1(Hazardous Substances Data)

Upstream product

• 10300-22-8 3'-O-methyladenosine 
• 685-83-6 bis(diethylamino)chlorophosphine 
• 1166393-99-2 2'-O-levulinoyl-N₆-[(4-methoxyphenyl)(diphenyl)methyl]-3'-O-methyladenosine 
• 1166393-98-1 C₄₂H₅₁N₅O₇Si 
• 1166393-97-0 5'-O-[ (tert-butyl)(dimethyl)silyl]-N₆-[(4-methoxyphenyl)(diphenyl)methyl]-3'-O-methyladenosine 
• 1166393-96-9 5'-O-[(tert-butyl)(dimethyl)silyl]-3'-O-methyladenosine 

Downstream Products

• 1373756-00-3 2'-O-levulinoyl-N₆-[(4-methoxyphenyl)(diphenyl)methyl]-3'-O-methyladenosine 5'-(bis{3-[(acetyloxy)methoxy]-2,2-bis(ethoxycarbonyl)propyl} phosphate) 
• 1373756-01-4 C₅₅H₆₈N₅O₂₂P 
• 1388227-08-4 C₆₃H₈₇N₇O₂₂P₂ 

Relevant articles and documents

Synthesis and enzymatic deprotection of fully protected 2′-5′ oligoadenylates (2-5A): Towards a prodrug strategy for short 2-5A

Fully protected pA2′p5′A2′p5′A trimers 1a and 1b have been prepared as prodrug candidates for a short 2′-5′ oligoadenylate, 2-5A, and its 3′-O-Me analog, respectively. The kinetics of hog liver carboxyesterase (HLE)-triggered deprotection in HEPES buffer (pH 7.5) at 37° has been studied. The deprotection of 1a turned out to be very slow, and 2-5A never appeared in a fully deprotected form. By contrast, a considerable proportion of 1b was converted to the desired 2-5A trimer, although partial removal of the 3′-O-[(acetyloxy)methyl] group prior to exposure of the adjacent phosphodiester linkage resulted in 2′, 5′→3′,5′ phosphate migration and release of adenosine as side reactions.