10300-22-8

Basic information

• Product Name: 3'-O-Methyl-D-adenosine
• Synonyms: 3'-O-Methyl-D-adenosine;3'-OMe-A
• CAS NO: 10300-22-8
• Molecular Formula: C₁₁H₁₅N₅O₄
• Molecular Weight: 281.2679
• Mol File: 10300-22-8.mol
• Article Data: 11

Chemical Properties

• Melting Point: 177-178 °C
• Boiling Point: 623.8 °C at 760 mmHg
• Flash Point: 331 °C
• Appearance: /
• Density: 1.84 g/cm³
• PKA: 12.98±0.70(Predicted)
• CAS DataBase Reference: 3'-O-Methyl-D-adenosine(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-O-Methyl-D-adenosine(10300-22-8)
• EPA Substance Registry System: 3'-O-Methyl-D-adenosine(10300-22-8)

Safety Data

• Hazardous Substances Data: 10300-22-8(Hazardous Substances Data)

Usage

Physical Form

Solid

Application

3'-O-Methyladenosine is a useful research chemical compound.

Upstream product

• 17287-03-5 trimethylsulphonium hydroxide 
• 58-61-7 adenosine 
• 80-48-8 methyl p-toluene sulfonate 
• 647834-80-8 O-levulinyl acetonoxime 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 74-88-4 methyl iodide 
• 74230-06-1 trimethylselenonium hydroxyde 
• 1899-02-1 trimethylphenylammonium hydroxide 
• 512-56-1 trimethyl phosphite 

Downstream Products

• 1166393-97-0 5'-O-[ (tert-butyl)(dimethyl)silyl]-N₆-[(4-methoxyphenyl)(diphenyl)methyl]-3'-O-methyladenosine 
• 1166393-98-1 C₄₂H₅₁N₅O₇Si 
• 1166393-99-2 2'-O-levulinoyl-N₆-[(4-methoxyphenyl)(diphenyl)methyl]-3'-O-methyladenosine 
• 1166394-11-1 C₄₄H₅₆N₇O₇P 
• 1373756-00-3 2'-O-levulinoyl-N₆-[(4-methoxyphenyl)(diphenyl)methyl]-3'-O-methyladenosine 5'-(bis{3-[(acetyloxy)methoxy]-2,2-bis(ethoxycarbonyl)propyl} phosphate) 
• 1373756-01-4 C₅₅H₆₈N₅O₂₂P 
• 1388227-08-4 C₆₃H₈₇N₇O₂₂P₂ 
• 2140-79-6 2'-O-methyl adenosine 
• 185761-10-8 3'-O-methyl-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 
• 60037-52-7 N⁶,O^3'-methyladenosine 
• 20649-46-1 2'-O,3'-O-dimethyladenosine 

Relevant articles and documents

Mixed alkylation (methylation and ethylation) of adenosine by diazoethane in aqueous 1,2-dimethoxyethane.

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Solid-phase synthesis of carbohydrate and phosphodiester modified 2'-5' oligoadenylate analogs

A series of 2'-5' oligoadenylate analogs containing internucleotide and ribose modifications were prepared by solid-phase methods as potential interferon mimetics. All syntheses were carried out using automated methodologies with precursors that allow for the generation of multiple combinations of modification.

Methylation of Adenosine and Related Nucleosides with Trimethylselenonium Hydroxyde, and Regiospecific Effects of Copper(II) Ions

Methylation of adenosine, deoxyadenosine, 6-N-methyladenosine and 2'(3')-O-methyladenosines with trimethylselenonium hydroxyde was studied in the presence and absence of copper(II) acetylacetonate .It was found that copper(II) ions promoted methylation of the 2'(3')-OH groups of the ribonucleosides but suppressed methylation at the N-1 position of the adenine rings.The metal-ion effects are discussed in conjunction with a catalytic role for Cu(AA)2 in the reactions.