116673-46-2

Basic information

• Product Name: 1,2-Ethanediol, 1-(3,4,5-trimethoxyphenyl)-
• CAS NO: 116673-46-2
• Molecular Formula: C11H16O5
• Molecular Weight: 228.245
• Mol File: 116673-46-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1,2-Ethanediol, 1-(3,4,5-trimethoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Ethanediol, 1-(3,4,5-trimethoxyphenyl)-(116673-46-2)
• EPA Substance Registry System: 1,2-Ethanediol, 1-(3,4,5-trimethoxyphenyl)-(116673-46-2)

Safety Data

• Hazardous Substances Data: 116673-46-2(Hazardous Substances Data)

Usage

General Description

1,2-Ethanediol, 1-(3,4,5-trimethoxyphenyl)-, also known as Mescaline, is a psychoactive alkaloid compound found in the peyote cactus and other related plants. It is a potent hallucinogen that has been used for centuries in traditional religious and spiritual ceremonies by indigenous peoples of the Americas. Mescaline produces an altered state of consciousness characterized by visual and auditory hallucinations, as well as changes in mood, thought, and perception. It is classified as a Schedule I substance in the United States due to its high potential for abuse and lack of accepted medical use. Despite its illegal status, mescaline continues to be used recreationally for its psychedelic effects, and research into its potential therapeutic applications is ongoing.

Upstream product

• 6814-64-8 methylenedimethyl sulfurane 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 13400-02-7 3,4,5-trimethoxy styrene 
• 1373919-38-0 2,3,4-trimethoxy-6-vinylbenzonitrile 

Downstream Products

• 116673-45-1 (+/-)-trans-2,5-bis(3,4,5-trimethoxyphenyl)-1,3-dioxolane 
• 116673-45-1 (2R,4S)-2,4-Bis-(3,4,5-trimethoxy-phenyl)-[1,3]dioxolane 
• 1415215-61-0 C₁₅H₂₀O₇ 
• 1415215-63-2 C₁₉H₂₆O₇ 
• 1415215-65-4 C₂₇H₄₂O₇ 
• 1415215-67-6 C₂₃H₂₈O₇ 
• 1415215-69-8 C₁₈H₂₆O₆ 
• 1415215-70-1 C₂₇H₃₂O₇ 
• 1415215-71-2 C₂₉H₃₆O₉ 
• 1415215-78-9 C₂₇H₄₀O₉Si 

Relevant articles and documents

1-(3,4,5-Trimethoxyphenyl)ethane-1,2-diyl esters, a novel compound class with potent chemoreversal activity

1-(3,4,5-Trimethoxyphenyl)ethane-1,2-diyl esters, which share a fragment from (±)-3′-O-4′-O-bis(3,4-dimethoxycinnamoyl)-cis- khellactone (DMDCK) and 3′R,4′R-disubstituted-2′,2′- dimethyldihydropyrano[2,3-f]chromone (DSP), exhibited remarkable chemoreversa

New antimitotic agents with activity in multi-drug-resistant cell lines and in vivo efficacy in murine tumor models

During a screen for compounds that could inhibit cell proliferation, a series of new tubulin-binding compounds was identified with the discovery of oxadiazoline 1 (A-105972). This compound showed good cytotoxic activity against non-multi-drug-resistant and multi-drug-resistant cancer cell lines, but its utility in vivo was limited by a short half-life. Medicinal chemistry efforts led to the discovery of indolyloxazoline 22g (A-259745), which maintained all of the in vitro activity seen with oxadiazoline 1, but also demonstrated a better pharmacokinetic profile, and dose-dependent in vivo activity. Over a 28 day study, indolyloxazoline 22g increased the life span of tumor-implanted mice by up to a factor of 3 upon oral dosing. This compound, and others of its structural class, may prove to be useful in the development of new chemotherapeutic agents to treat human cancers.