1166816-05-2Relevant academic research and scientific papers
Small-molecule androgen receptor downregulators as an approach to treatment of advanced prostate cancer
Bradbury, Robert H.,Hales, Neil J.,Rabow, Alfred A.,Walker, Graeme E.,Acton, David G.,Andrews, David M.,Ballard, Peter,Brooks, Nigel A.N.,Colclough, Nicola,Girdwood, Alan,Hancox, Urs J.,Jones, Owen,Jude, David,Loddick, Sarah A.,Mortlock, Andrew A.
, p. 5442 - 5445 (2011)
Chemical starting points were investigated for downregulation of the androgen receptor as an approach to treatment of advanced prostate cancer. Although prototypic steroidal downregulators such as 6a designed for intramuscular administration showed insuff
BICYCLIC DERIVATIVES FOR USE IN THE TREATMENT OF ANDROGEN RECEPTOR ASSOCIATED CONDITIONS
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Page/Page column 308, (2009/07/25)
The invention concerns bicyclic compounds of Formula (I), wherein the integers X1, X2, X3, Ring A, R4, R5 and m are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the prevention or treatment of androgen-receptor associated conditions.
