1166833-22-2Relevant academic research and scientific papers
Internal cysteine accelerates thioester-based peptide ligation
Haase, Christian,Seitz, Oliver
supporting information; experimental part, p. 2096 - 2101 (2009/10/04)
Thioester-mediated peptide coupling reactions are powerful tools in protein synthesis. The fragment coupling occurs extremely fast at ligation sites that contain an N-terminal cyste- ine residue. This native chemical ligation involves a capture step that
